Serological survey of antibodies to influenza A viruses in a group of people without a history of influenza vaccination |
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| Authors: | Y Chen Q Zheng K Yang F Zeng S-Y Lau WL Wu S Huang J Zhang H Chen N Xia |
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| Institution: | 1. National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, Xiamen University, Xiamen, Fujian Province;2. Xiamen International Travel Health Care Centre, Xiamen, Fujian Province;3. State Key Laboratory for Emerging Infectious Diseases, Department of Microbiology, University of Hong Kong, Pokfulam, Hong Kong, China |
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| Abstract: | A serological survey for antibodies to influenza viruses was performed in China on a group of people without a history of influenza vaccination. Using the haemagglutination inhibition (HI) assay, we found seropositivity rates for seasonal H3N2 to be significantly higher than those for seasonal H1N1. Samples positive for antibodies to the pandemic (H1N1) 2009 virus increased from 0.6% pre-outbreak to 4.5% (p <0.01) at 1 year post-outbreak. Interestingly, HI and neutralization tests showed that 1.4% of people in the group have antibodies recognizing H9N2 avian influenza viruses, suggesting that infection with this subtype may be more common than previously thought. |
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| Keywords: | Antibody H9N2 influenza pandemic H1N1 prevalence |
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