Clinical impact of a highly prevalent Pseudomonas aeruginosa clone in Dutch cystic fibrosis patients |
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| Authors: | A.M.M. de Vrankrijker R.W. Brimicombe T.F.W. Wolfs H.G.M. Heijerman R. van Mansfeld F.T. van Berkhout R.J.L. Willems M.J.M. Bonten C. K. van der Ent |
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| Affiliation: | 1. Department of Paediatric Respiratory Medicine, University Medical Centre Utrecht, Utrecht;2. Department of Medical Microbiology, Haga Teaching Hospital, The Hague;3. Department of Paediatric Infectious diseases, University Medical Centre Utrecht, Utrecht;4. Department of Pulmonology, Haga Teaching Hospital, The Hague;5. Department of Medical Microbiology, Utrecht, The Netherlands;6. Department of Pulmonology, University Medical Centre Utrecht, Utrecht, The Netherlands |
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| Abstract: | Studies suggest that infection with highly prevalent Pseudomonas aeruginosa clones in cystic fibrosis (CF) is associated with an unfavourable clinical outcome. We studied the clinical characteristics of patients infected with a recently described, highly prevalent P. aeruginosa clone (ST406) in two CF centres in The Netherlands. Multilocus sequence typing data were available for 219 patients, of whom 40 (18.3%) were infected with ST406 and 179 with other sequence types. ST406 infection was independently associated with age, having a sibling with ST406 infection and use of inhaled antibiotics, but not with unfavourable clinical outcome, suggesting that high transmissibility is not necessarily associated with high virulence. |
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| Keywords: | Clone cross-infection cystic fibrosis MLST Pseudomonas aeruginosa |
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