Angiopep-2用于脑靶向递药系统的研究进展

随着社会的发展，脑部疾病已成为影响人类生活质量和健康的重要因素。一般给药系统很难穿透血脑屏障抵达病变部位，但靶向递药系统的出现，实现了药物在脑内递释，从而达到治疗的效果。Angiopep是一类能与低密度脂蛋白受体结合介导穿透血脑屏障的相关肽家族，其中angiopep-2可用于药物脑靶向递送，改善药物转运及精准作用于病变部位。简介angiopep-2的生物学性质及转运形式，重点介绍其穿透血脑屏障和靶向递药的治疗作用研究进展。

Advances in the Research on Angiopep-2 in Brain Targeting Delivery System

With the development of society,brain diseases have become an important factor affecting the quality of our life and health.It is difficult for general drug delivery systems to cross the blood-brain barrier to reach lesions,but the emergence of targeting drug delivery systems has achieved drug delivery in the brain to achieve therapeutic effects.Angiopep is a family of related peptides that can bind to the low-density lipoprotein receptor and mediate the permeability of the blood-brain barrier.Angiopep-2,one of the members of the peptide family,can be used for glial administration to improve drug delivery and accurately affect the lesion.Based on the biological properties and transport forms of angiopep-2,this article introduces its permeability to the blood-brain barrier and the therapeutic effects of targeting drug delivery.