Serodiagnosis of respiratory syncytial virus (RSV) infection in children as measured by detection of RSV-specific immunoglobulins G, M, and A with enzyme-linked immunosorbent assay. |
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| Authors: | M J Meddens P Herbrink J Lindeman and W C van Dijk |
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| Institution: | Department of Pathology, Clinical Microbiology and Clinical Immunology, Stichting Samenwerking Delftse Ziekenhuizen, Delft, The Netherlands. |
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| Abstract: | The diagnostic value of an enzyme-linked immunosorbent assay for detection of respiratory syncytial virus (RSV)-specific immunoglobulin G (IgG), IgM, and IgA in sera from infants and children with proven RSV infection, from a control group, and from patients with symptoms of viral respiratory disease was analyzed. Compared to virus isolation and RSV antigen detection methods, the sensitivity of this assay was 87% and the specificity was 79%. For IgG alone, these were 45 and 92%, for IgM alone they were 48 and 92%, and for IgA alone they were 74 and 95%, respectively. |
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