不同血液净化方式对血β_2-微球蛋白清除的影响

目的比较低通量血液透析（HD）、高通量血液透析（HFHD）和血液灌流与血液透析串联（HP／HD）3种血液净化方式对维持性血液透析患者尿素氮、肌酐和β2-微球蛋白清除的影响。方法将血液净化中心68例维持性血液透析患者随机分成3组，分别是HD组24例，HFHD组22例，HP／HD组22例。在透析前后分别取血检测患者尿素氮、肌酐及β2-微球蛋白。结果3组患者透析前后尿素氮、肌酐均明显下降。HFHD和HP／HD组患者循环中β2-微球蛋白透析显著下降，而HD组透析前后β2-微球蛋白差异无显著性。结论HD、HFHD、HP／HD均能有效清除维持性血液透析患者血液中小分子溶质，而HFHD、HP／HD对β2-微球蛋白清除能力明显优于HD。

Different Dialysis Modes on Serum β2-Microglobuli

Objective To compare the effects of different dialysis modes, low - flux hemodialysis（HD）, high -flux hemodialysis（HFHD） and hemopeffusion combined hemodialysis（HP/HD） on serum β2-microglobulin. Methods 68 maintenance hemodialysis patients were randomly assigned to low - flux hemodialysis group（ HD n = 24）, high - flux hemodialysis group （ HFHD n = 22） and hemoperfusion combined hemodialysis group （ HP/HD n = 22） .The serum blood urea nitrogen,creatinine and β2-microglobulin were examined pre and post dialysis. Results The serum blood urea nitrogen, creatinine all reduced through dialysis in three groups. The concentration of serum β2-microglobulin significantly reduced after the dialysis session in the HFHD group and HP/HD group while no sighificance was found in the HD group. Conclusion HD, HFHD and HP/HD all could efficiently eliminate the low molecular weight solutes. While HFHD and HP/HD also could efficiently eliminate the β2-microglobulin in the maintenance hemodialysis patients.