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| 宫颈癌术前动脉介入栓塞化学治疗和静脉化学治疗疗效比较 | |
| 引用本文： | 秦海霞,夏永华,杨君,任艳芳,华方方,崔红凯,潘莹.宫颈癌术前动脉介入栓塞化学治疗和静脉化学治疗疗效比较[J].新乡医学院学报,2013,30(1):38-41. |
| 作者姓名： | 秦海霞 夏永华 杨君 任艳芳 华方方 崔红凯 潘莹 |
| 作者单位： | 1. 新乡医学院第一附属医院妇产科,河南卫辉,453100 2. 新乡医学院第一附属医院皮肤科,河南 卫辉,453100 3. 新乡医学院第一附属医院影像介入中心,河南卫辉,453100 4. 新乡医学院第三附属医院妇产科,河南新乡,453003 |
| 基金项目： | 河南省卫生厅科技攻关项目(编号:200802009);河南省教育厅自然科学研究计划项目(编号:2008A320011) |
| 摘 要： | 目的比较2种新辅助化学治疗方法对Ⅰb2～Ⅱb期宫颈癌患者的疗效及化学治疗不良反应。方法回顾性分析136例Ⅰb2～Ⅱb期宫颈鳞状细胞癌患者的临床资料,其中术前行动脉介入栓塞化学治疗(介入组)58例,静脉化学治疗(全身化学治疗组)78例,比较2组的临床疗效、化学治疗不良反应、可手术率、化学治疗后至手术实施间隔时间。结果介入组有效率为84.48%,全身化学治疗组有效率为80.77%,2组有效率比较差异无统计学意义(P>0.05);介入组手术率为96.55%,全身化学治疗组手术率为93.59%,2组手术率比较差异无统计学意义(P>0.05)。介入组术前住院时间、化学治疗不良反应、化学治疗后至手术时间均明显少于全身化学治疗组(P<0.01),住院总费用介入组明显高于全身化学治疗组,差异有统计学意义(P<0.05)。结论 2种新辅助化学治疗方法对Ⅰb2～Ⅱb期宫颈癌的治疗均安全有效;动脉介入化学治疗疗程短,不良作用小,见效快,对于经济条件较好的宫颈癌患者术前辅助治疗更为适合。 |
| 关 键 词： | 宫颈癌 新辅助化学治疗 动脉介入栓塞化学治疗 静脉化学治疗 |
Comparison of curative effect between artery interventional embolization chemotherapy and intravenous chemotherapy preoperative in cervical cancer |
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| QIN Hai-xia,XIA Yong-Hua,YANG Jun,REN Yan-fang,HUA Fang-fang,CUI Hong-kai,PAN Ying.Comparison of curative effect between artery interventional embolization chemotherapy and intravenous chemotherapy preoperative in cervical cancer[J].Journal of Xinxiang Medical College,2013,30(1):38-41. | |
| Authors: | QIN Hai-xia XIA Yong-Hua YANG Jun REN Yan-fang HUA Fang-fang CUI Hong-kai PAN Ying |
| Institution: | 1.Department of Obstetrics and Gynecology,the First Affiliated Hospital of Xinxiang Medical University,Weihui 453100,Henan Province,China;2.Department of Dermatology,the First Affiliated Hospital of Xinxiang Medical University,Weihui 453100,Henan Province,China;3.Image Intervention Center,the First Affiliated Hospital of Xinxiang Medical University,Weihui 453100,Henan Province,China;4.Department of Obstetrics and Gynecology,the Third Affiliated Hospital of Xinxiang Medical University,Xingxiang 453003,Henan Province,China) |
| Abstract: | Objective To compare the efficacy and adverse effect of two kinds of neoadjuvant chemotherapy pathway for Ⅰ b2-Ⅱ b stage cervical cancer patients.Methods Retrospective analysis of the clinical data of 136 cases withⅠ b2-Ⅱ b cervical squamous cell carcinoma.Fifty-eighty cases were given arterial interventional chemotherapy(intervention group) and 78 cases were given intravenous chemotherapy(systemic chemotherapy group).The clinical efficacy,adverse reaction of chemotherapy,operability and the interval time from chemotherapy to surgery were compared between the two groups.Results The effective rates in intervention group and systemic chemotherapy group were 84.48% and 80.77% respectively.There was no significant difference of effective rate between the two groups(P>0.05).The operability in the intervention group and systemic chemotherapy group were 96.55% and 93.59% respectively.There was no significant difference of operability between the two groups(P>0.05).The length of stay before operation,adverse reaction of chemotherapy,and the time from chemotherapy to surgery in intervention group were less than those in systemic chemotherapy group(P<0.05),but the total charge was higher than that in systemic chemotherapy group(P<0.05).Conclusion The two kinds of neoadjuvant chemotherapy are safe and effective in treating patients with Ⅰ b2-Ⅱ b stage cervical cancer.The arterial interventional chemotherapy has shorter course of treatment,less side effects,faster efficacy.As a method of preoperative adjuvant chemotherapy,it is more appropriate for cervical cancer patients with better economic conditions. |
| Keywords: | cervical cancer neoadjuvant chemotherapy artery interventional embolization chemotherapy intravenous chemotherapy |
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