| 反社会人格障碍患者的脑灰质结构研究 |
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| 引用本文： | 廖坚,罗贤明,王维,吴大兴,柯铭,吕云霄,周建松. 反社会人格障碍患者的脑灰质结构研究[J]. 中华精神科杂志, 2008, 42(1): 89-91. DOI: 10.3760/cma.j.issn.1006-7884.2009.02.010 |
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| 作者姓名： | 廖坚 罗贤明 王维 吴大兴 柯铭 吕云霄 周建松 |
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| 作者单位： | 中南大学湘雅三医院放射科,长沙,410013;湘雅二医院精神卫生研究所;国防科技大学机电工程与自动化学院自动控制系; |
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| 摘 要： | 目的 研究反社会人格障碍(APD)患者与正常人大脑灰质结构的异同.方法 对17例APD患者(APD组)和19名与APD组的年龄、性别、智商及文化程度匹配的正常对照者(正常对照组)进行脑部T1加权像及3维结构像扫描,并使用基于体素的形态学分析法进行数据分析.结果 APD组左额上回(BA8)、右楔前叶、左眶额回、双侧额中同、右额内侧同、右侧顶下小叶、左梭状回、双侧颞上回及双侧小脑的灰质密度低于正常对照组,而左额上回(BA38)及左海马旁回的密度高于正常对照组(P<0.005).结论 APD患者存在脑结构的异常,主要包括前额叶、眶额回、楔前叶、颞叶及双侧小脑.
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| 关 键 词： | 反社会性人格障碍 磁共振成像 端脑 |
Morphological changes of cerebral gray matter in patients with antisocial personality disorder |
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| Abstract: | Objective To investigate the morphological changes of cerebral gray matter in people with antisocial personality disorder in comparison to normal control.Methods Voxel based morphometry in conjunction with statistical parametric mapping was applied to the structural magnetic resonance images of 17 persons with antisocial personality disorder and 19 normal.controls.Results Compared with the controh,the cerebral gray matter concentrations were significantly decreased in the left superior frontal cortex,bilateral middle frontal cortex,left orbitofrontal codex,bilateral cerebellum,fight inferior parietal lobule and bilateral superior temporal cortex of people with antisocial personality.Conclusion The results suggest the gray matter of the prefrontal cortex,orbitofrontal cortex,precuneus and cerebellum is lost in some degree in people with antisocial personality disorder patients. |
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| Keywords: | Antisocial personality disorderMagnetic resonance imagingTelencephalon |
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