Effect of serotonin on respiration,cerebral circulation,and blood pressure in rats |
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| Authors: | V. V. Aleksandrin N. N. Tarasova I. A. Tarakanov |
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| Affiliation: | (1) State Research Institute of General Pathology and Pathological Physiology, Russian Academy of Medical Sciences, Moscow;(2) V. V. Zakusov State Research Institute of Pharmacology, Russia |
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| Abstract: | The effects of intravenous serotonin on respiration, cerebral circulation, and blood pressure were examined in narcotized rats. Serotonin rapidly decreased local cerebral blood flow (by almost 30%) and blood pressure. Hemodynamic phenomena were accompanied by sharp changes in the respiration pattern: short-term apnea in all cases. The mechanism of this apnea was related to initial stages in blood pressure changes and had a neurogenic nature.__________This revised version was published online in July 2005 with the addition of the issue titleTranslated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 139, No. 1, pp. 72–76, January, 2005 |
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| Keywords: | serotonin cerebral circulation respiration apnea rat |
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