急诊PCI术后患者N-proBNP变化及其同预后关系

目的:观察急诊PCI术后患者N-proBNP水平及其对患者预后的关系.方法:急性冠脉综合症(ACS)患者84例,按ACS治疗分为6组:PCI且UA组;非PCI且UA组;PCI且NSTEMI组;非PCI且STEMI组;PCI且STEMI组;非PCI且STEMI组.依次测量入院时、入院后24 h、7 d的N-proBNP水平.结果:STEMI组和NSTEMI组血浆N-proBNP水平高于UA组.无论是否行PCI术,患者入院后24 h的N-proBNP显著增高;7 d时N-proBNP水平较入院时明显下降.行PCI者入院后24 h和7 d的N-proBNP水平与同时期未行PCI者比较有显著性差异(P<0.05).90 d内发生猝死、有症状性心力衰竭、恶性心律失常的患者第7 d N-proBNP水平,与未发生心脏相应事件的患者的N-proBNP水平相比有明显的升高(P<0.05).结论:N-proBNP水平在ACS患者中明显升高,其升高程度与ACS类型相关,PCI介入治疗可以使血浆中N-proBNP水平下降,N-proBNP可作为判断ACS患者预后的指标.

Plasma Level of N-proBNP in Patients with Acute Coronary Syndrome and Percutaneous Coronary Intervention, and Its Clinical Significance

Objective：To observe the emergency patients after PCI N-proBNP levels and its effect on prognosis.Methods：Acute coronary syndrome（ACS） in 84 patients,according to ACS treatment were divided into 6 groups： group PCI and UA;PCI and UA group;PCI and NSTEMI group;PCI and STEMI group;PCI and STEMI group;PCI and STEMI group.Are measured at admission,24 hours after admission,7 days N-proBNP level.Results：In STEMI group and NSTEMI group,the plasma level of N-pro BNP was higher than that of UA group.Whether or not PCI surgery,patients24 hours after admission to the N-proBNP increased significantly;7 days when N-proBNP levels were significantly decreased at the time of admission.The line PCI24 hours after admission and 7 days at the N-proBNP level with the same period without PCI had significant difference（P0.05）.Within 90 days of the occurrence of sudden death,has the symptoms of heart failure,malignant arrhythmia patients seventh days N-proBNP levels,not associated with the occurrence of cardiac events in patients with corresponding N-proBNP level compared with significantly increased（P0.05）.Conclusions：The level of N-proBNP in ACS patients were significantly elevated,the elevated level of ACS type,PCI interventional treatment can make the decrease in plasma N-proBNP level,N-proBNP can be used to judge the prognosis of patients with ACS index.