阿奇霉素治疗11例弥漫性泛细支气管炎患者的分析

目的本研究旨在探讨阿奇霉素治疗弥漫性泛细支气管炎(DPB)的疗效。方法分析入住我院呼吸科11例DPB患者资料,比较阿奇霉素治疗6个月前后肺功能及胸部影像学的变化。结果治疗后肺功能检查第1秒用力呼气量(FEV1)占预计值%(84.31%±5.17%vs 73.44%±4.21%)、用力肺活量(FVC)占预计值%(86.27%±5.22%vs 75.10%±4.92%)、FEV1/FVC(73.14%±4.08%vs 62.44%±3.58%)、呼出75%肺活量时的用力呼气流速占预计值%(53.16%±4.96%vs 40.86%±3.57%)较治疗前升高,而残气量(RV)/肺总量(TLC)(47.15%±2.18%vs 48.01%±3.11%)较治疗前变化不大。10例患者胸部影像学明显改善。结论阿奇霉素可有效改善DBP患者的肺功能和胸部CT表现,阻止病变进展,改善预后。

Retrospective analysis of azithromycin in the treatment of 11 patients with diffuse panbronchiolitis

Objective To investigate the curative effect of azithromycin in the treatment of patients with diffuse panbrochiolitis （DPB）. Methods The clinical data of 11 patients with DPB hospitalized in respiratory department were retrospectively analyzed. The changes of lung function and chest imaging features were compared before and 6 months after the treatment. Results Before and 6 months after the treatment, the predicted percentage of forced expiratory volume in one second （ FEV1 ） was 84.31%±5.17% vs 73.44% ± 4.21% ）. The predicted percentage of forced vital capacity （FVC） was 86. 27%±5.22% vs 75.10% ±4.92%. The value of FEVI/ FVC was 73.14% ±4.08% vs 62.44% ±3.58% and the predicted percentage of forced expiratory volume with 75% vital capacity was 53. 16% ±4. 96% vs 40. 86% ± 3.57%. The ratio of residual volume to total lung capacity was 47.15% ±2. 18% vs 48.01% ± 3.11%. 10 patients had a significant improvement of chest imaging features. Conclusion Azithromycin can improve lung functions and chest imaging in the treatment of patients with DPB, so it can halt the progression and improve the prognosis of patients with DPB.