2项检测对2型糖尿病并发糖尿病足的意义

目的通过分析2型糖尿病(T2DM)患者糖化血红蛋白(HbA1c)和生化检测指标,以探讨T2DM并发糖尿病足(DFU)发病的危险因素,为临床诊治提供指导。方法选取178例T2DM患者,其中78例为糖尿病足患者(DF组),100例为2型糖尿病患者无糖尿病足(DC组)。分别测定HbA1c和血压一般生化指标:同型半胱氨酸(Hcy)、脂蛋白aLP(a)]、载脂蛋白B(Apo B)和空腹血糖(FBG)等。然后比较两组各指标间的差异,采用Loges-tic分析具有差异的指标。结果 DC组和DF组Hcy、HbA1c和LP(a)等7项指标差异有统计学意义(P<0.05)。HbA1c(OR=2.01)和Hcy(OR=1.85)为T2DM患者发生足部溃疡的主要危险因素。结论在普通生化检测指标中Hcy及血浆HbA1c的检测对DFU的诊治最具指导意义。

The significance of hemoglobin Alc and homocysteine in type 2 diabetes patients with complication of diabetic foot ulcers

Objective To investigate the most effective elements on diabetic foot ulcers （HFU） in type 2 dia- betes mellitus （T2DM） patients and give some advices to clinical diagnosis and treatments by detection of hemoglobin Alc （HbAlc） and the general biochemistry in blood. Methods 78 diabetic individuals with HFU and 100 diabetic in- dividuals without HFU were enrolled. Plasma HbAlc and the general chemistry such as homocysteine （Hcy）, lipo- protein a I.P（a）],apolipoprotein B （Apo B） and fasting blood glucose （FBG） and so on were detected. Results of the two groups were compared and the results with distinction were analyzed by Logistic analysis. Results All seven indexes of routine chemistry were with significant difference between the two groups （P〈 0. 05）. HbAlc （OR = 2.01）and Hcy（OR= 1.85）were the most risk factors for T2DM result in HFU. Conclusion In the diagnosis and treatment of DF_l, among the general chemistry indexes, Hcy could be the most valuable and the concentration of HbAI c could be another index with high relevance.