单相与双相障碍抑郁发作患者睡眠特征研究

目的探讨单相与双相障碍抑郁发作患者的睡眠特征。方法将46例单相抑郁发作患者设为单相抑郁组，28例双相障碍抑郁发作患者设为双相抑郁组，同期选取本院健康职工20名设为对照组，对3组进行汉密顿抑郁量表、睡眠状况自评量表测评并分析多导睡眠图。结果多导睡眠图描记观察指标中，3组睡眠总时间、睡眠期时间、慢波睡眠时间、入睡后觉醒时间、非快速眼动睡眠时间、睡眠效率、睡眠潜伏期、快速眼球运动潜伏期、快速眼球运动时间、快速眼球运动周期数、N2睡眠比例、N3潜伏期、N3睡眠时间、N3睡眠比例、觉醒睡眠比例、微觉醒总时间比较差异有显著性（P〈0．05或0．01），单相抑郁组慢波睡眠时间、N2睡眠比例、N3睡眠时间、N3睡眠比例与双相抑郁组比较差异有显著性（P〈O．05或0．01）。结论单相与双相障碍抑郁发作患者常存在各种睡眠问题，与健康者比较多导睡眠图有特征性的改变。单相与双相障碍抑郁发作患者多导睡眠图相似，但单相抑郁发作患者的深睡眠更少。

Sleep characteristics of unipolar and bipolar depression patients

Objective To explore the sleep characteristics of unipolar and bipolar depression patients. Methods Forty-six unipolar depression patients were as- signed to unipolar depression group, 28 bipolar depression ones to bipolar depression group and simultaneously selected 20 healthy employees of our hospital to control group. Assessments were conducted with the Hamilton Depression Scale （HAMD） and Self-Rating Scale of Sleep （SRSS） for three groups, polysomnograms analyzed. Results There were significant differences in TST, SPT, SWS, WASO,NREM,SE, SL, REML, REMT, REMP, N2%, N3L, N3T, N3% , REML W/S, micro-arousal total time among （P〈0.05 or 0.01） and in SWS, N2%, N3S and N3% between unipolar and bipolar depression, group （P〈0.05 or 0.01）. Conclusion Unipolar and bipolar depression patients often have obvi ous sleep problems and characteristic change of polysomnogram compared with the healthy persons. Poly- somnograms of unipolar and bipolar depression patients are similar,but unipolar depression patients have less deep sleep.