200例类风湿关节炎抗突变型瓜氨酸波形蛋白抗体检测结果分析

目的分析200例类风湿关节炎(RA)患者抗突变型瓜氨酸波形蛋白(抗MCV)抗体检测结果,探讨抗MCV抗体在RA诊断中的临床意义。方法收集200例RA患者血清标本,120例健康体检者血清标本检测其抗MCV抗体和类风湿因子(RF),计算并绘制受试者ROC曲线下面积。结果抗MCV抗体和RF的灵敏度分别为86.0%和70.5%,特异性分别为92.5%和48.3%,Kappa系数分别为0.78和0.28。抗MCV抗体的ROC曲线下面积为0.933(95%置信区间为0.875～0.975)。结论抗MCV抗体是诊断RA的良好指标,具有很高的灵敏度和特异性,优于RF,对于辅助诊断RA具有重大意义。

Analysis of anti-MCV antibody among 200 patients with rheumatoid arthritis

Objective To analyze the results of anti-mutant citrulline vimentin （anti-MCV） antibody among 200 patients with rheumatoid arthritis （RA）, and to explore the clinical significance of this antibody for RA. Methods 200 patients with RA and 120 cases of healthy serum samples were detected for anti-MCV antibody and rheumatoid factor （RF）, then the area under receiver operating characteristic（ROC） curve was calculated. Results The sensitivity of anti-MCV antibody and RF were 86.0% and 70.5~ ,the specificity were 92.5% and 48.3%, the Kappa was 0.78 and 0.28, and the area under ROC curve for anti-MCV antibody was 0. 933 （95% confidence range 0. 875--0.0. 975）. Conclusion Anti-MCV antibody could he a good indicator for the RA which could have good sen- sitivity and specificity. It might be better than RF, and be a good indicator for clinical diagnosis of RA.