西酞普兰与舍曲林治疗老年期双相障碍抑郁发作对照研究

目的探讨西酞普兰与舍曲林治疗老年期双相障碍抑郁发作患者的临床疗效与安全性。方法将60例老年期双相障碍抑郁发作患者随机分为两组，每组30例，分别VI服西酞普兰和舍曲林治疗，观察6周。采用汉密顿抑郁量表、临床大体印象量表疾病严重程度分量表评定临床疗效，副反应量表评定不良反应。结果治疗后两组各量表评分均较治疗前显著下降（P〈0．01），西酞普兰组治疗1周末较舍曲林组下降更显著（P〈0．05）；西酞普兰组总有效率为93．3％，舍曲林组为90％，两组比较差异无显著性（P〉0．05）；两组不良反应均轻微，无需特殊处理。结论西酞普兰与舍曲林治疗老年期双相障碍抑郁发作疗效均显著，总体疗效相当，但西酞普兰起效更快，安全性高，依从性好。

A control study of escitalopram vs. sertraline in the treatment of senile bipolar depression

Objective To explore the efficacy and salety oI escl~alopram w senile bipolar depression. Methods Sixty senile bipolar depression patients were randomly divided into two groups of 30 ones each taking orally escitalopram or sertraline for six weeks. Efficacies were assessed with the Hamilton Depression Scale （HAMD） and Clinical Global Impression severity of illness （CGI-SI） and adverse reactions with the Treatment Emergent Symptom Scale （TESS）. Results Scores of all scales of both groups lowered more significantly after treatment compared with pretreatment （P〈0.01）, so did those in escitalopram than sertraline group at the end of the 1st week （P〈0.05） ; total effective rate was respectively 93.3% in escitalopram and 90 % sertraline group, which showed no significant difference （P〈 0.05） ; adverse reactions of both groups were mild and didn＇t need treatment. Conclusion Both escitalo- pram and sertraline have an evident and equivalent effect, but the former takes effect more rapidly and has higher safety and better compliance.