Effect of low-dose ketamine on inflammatory response in off-pump coronary artery bypass graft surgery |
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Authors: | Cho, J. E. Shim, J. K. Choi, Y. S. Kim, D. H. Hong, S. W. Kwak, Y. L. |
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Affiliation: | 1 Department of Anaesthesiology and Pain Medicine 2 Anaesthesia and Pain Research Institute, Yonsei University College of Medicine, 134 Shinchon-Dong, Seodaemun-Ku, Seoul 120-752, Republic of Korea |
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Abstract: | Background: Off-pump coronary artery bypass graft surgery (OPCAB) is stillassociated with a marked systemic inflammatory response. Theaim of this study was to investigate whether pre-emptive, lowdose of ketamine, which has been reported to have anti-inflammatoryactivity in on-pump coronary artery bypass surgery, could reduceinflammatory response in low-risk patients undergoing OPCAB. Methods: In this prospective randomized-controlled trial, 50 patientswith stable angina and preserved myocardial function undergoingOPCAB were randomly assigned to receive either 0.5 mg kg–1of ketamine (Ketamine group, n=25) or normal saline (Controlgroup, n=25) during induction of anaesthesia. Inflammatory markersincluding C-reactive protein (CRP), interleukin (IL)-6, tumournecrosis factor- (TNF- ), and cardiac enzymes were measured previousto induction (T1), 4 h after surgery (T2), and the first andsecond days after the surgery (T3 and T4). Results: There were no significant intergroup differences in the serumconcentrations of the CRP, IL-6, and TNF- and cardiac enzymes.Pro-inflammatory markers and cardiac enzymes, except TNF- , wereall increased after the surgery compared with baseline valuesin both groups. Conclusions: Low-dose ketamine administered during anaesthesia inductiondid not exert any evident anti-inflammatory effect in termsof reducing the serum concentrations of pro-inflammatory markersin low-risk patients undergoing OPCAB. |
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Keywords: | anaesthetics i.v., ketamine heart, coronary artery bypass |
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