Influence of carbon dioxide on the MIC of telithromycin for Streptococcus pneumoniae: an in vitro-in vivo study |
| |
| Authors: | Batard Eric Juvin Marie Emmanuelle Jacqueline Cédric Bugnon Denis Caillon Jocelyne Potel Gilles Drugeon Henri B |
| |
| Affiliation: | Laboratoire d'Antibiologie, UER de Médecine, 1 rue Gaston Veil, 44035 Nantes Cedex 01, France. ebatard@chu-nantes.fr |
| |
| Abstract: | Incubation in CO(2) resulted in higher (> or =3 doubling dilution) MICs of telithromycin than those found in ambient air for 31.2% of 346 Streptococcus pneumoniae ermB-positive strains. An increased telithromycin MIC in CO(2) was not correlated with loss of its activity in the murine sepsis/peritonitis model. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
