481例前列腺癌患者年龄与病理构成分析

目的:探讨近年来前列腺癌发病年龄和病理构成情况。方法:收集1998年1月~2004年4月经病理确诊的前列腺癌患者481例,对其年龄和病理构成进行分析。结果:1998年共有前列腺癌患者39例,1999年69例,2000年73例,2001年68例,2002年72例,2003年121例,2004年1~4月39例。患者年龄40~91岁,中位年龄72岁,95%的患者年龄为55~84岁,65岁以上患者占84.2%。病理分级中高分化14例,中分化29例,低分化83例,未进行病理分级355例。微小癌(小于1cm)40例(8.3%),偶发癌20例(4.2%)。病理类型中内膜样癌1例,鳞癌1例,印戒细胞癌1例,腺鳞癌1例,前列腺小细胞癌1例,粘液腺癌1例,腺样囊性癌1例,移行细胞癌1例,腺癌473例(98.1%)。结论:本组前列腺癌主要发生在65岁以上老年男性,病理类型绝大多数为腺癌,前列腺癌已成为危害老年男性健康的重要恶性肿瘤疾病。

Age and Pathological Features of 481 Prostate Cancer Patients

Objective: To investigate the age and pathological features of prostate cancer patients in recent years. Methods: An analysis was made of the age and pathological features of 481 cases of prostate cancer pathologically diagnosed from January 1998 to April 2004, 39 cases in 1998, 69 in 1999, 73 in 2000, 68 in 2001, 72 in 2002, 121 in 2003, and 39 in the first four months of 2004. Results: The patients ranged in age from 40 to 91 years, averaging 72, 95% between 55 and 84, and 84.2% over 65 years. Pathologically, 14 cases were well, 29 moderately, and 83 poorly differentiated according to the three-grade system (WHO, the Mostofi system), with 355 cases ungraded. Forty cases ( 8.3%) were microcarcinoma (< 1 cm), and 20 cases ( 4.2%) incidental carcinoma. Of the total number, 473 cases( 98.1%) were pathologically diagnosed as adenocarcinoma, 1 endometrioid adenocarcinoma, 1 squamous cell carcinoma, 1 signet ring cell carcinoma, 1 adenosquamous cell carcinoma, 1 small cell carcinoma, 1 mucinous adenocarcinoma, 1 adenoid cystic carcinoma, and 1 transitional cell carcinoma. Conclusion: Prostate cancer commonly develops in men over 65 years, and adenocarcinoma is the most common histological type. The disease has become a major malignant tumor to endanger elderly males.