应用聚氨基酸膜预防术后椎管粘连的实验报告

１８只成年白兔平均分三组。椎扳切除后，实验组在硬膜外覆盖聚氨基酸膜，硅胶组用硅胶膜覆盖，空白组无覆盖物。术后３０ｄ、６０ｄ处死动物。结果显示：实验组及硅胶组的硬脊膜均光滑无增厚，硬膜外间隙未见新生纤维组织增生或粘连。聚氨基酸膜于１个月降解吸收，形成硬膜外＂空隙＂，硅胶则不吸收。空白组的硬脊膜增厚，硬膜外纤维组织增生或粘连明显，硬膜外间隙消失。因此，可降解的聚氨基酸膜能有效地预防术后椎管瘢痕粘连的形成，又不存留异物，是一种较理想的生物材料。

An experimental report on the prevetion of postopertive adhesion in spinal canal by poly leuceine methylglutamate glutamic membrane

rabbits were divided into three groups.The epidural cavity following laminectomy covered by poly leucine methylglutamate glutamic(PLMGG) group,silicone rubber group and no coverings in the control group.The animals were sacrificed in 30 days and 60 days respectively after the opreation.The results showed that the dura was smooth and free from thickening in both PLMGG and silicone rubber groups.Also,there was no any fibrous proliferation and adhesion in the epidual cavity.The PLMGG membrane was degraded and absorbed after one month and a "gap" was formed in the epidural cavity,while the silicone membrane was not absorbed.The dura was thickend and there was obvious fibrous proliferation and adhesion in the epidural cavity in control group.Therefore,degradable PLMGG is an ideal biological material because of its no residual and preventing effectively the dura from postoperative fibrous adhesion.Auther's address(Department of Orthopaedics,First Affiliated Hospital of Sun yat-sen University of Medical Science,Guangzhou,Guangdong,510080)