精神分裂症症状与认知功能损害的关系

目的：探讨精神分裂症症状与认知功能损害的关系。方法：对１８例阴性精神分裂症和１５例阳性精神分裂症采用氯氮平治疗；对１１例阴性精神分裂症和１３例阳性精神分裂症采用利培酮治疗。并分别评估其治疗前和治疗８周后的阳性症状，阳性症状记忆，注意及执行功能。结果：精神分裂症的记忆损害与阴性症状和阳性症状都呈显著性相关，注意及执行功能损害与阴性症状显著相关，与阳性症状无明显相关；记忆随思维贫乏的改善而改善，注意和执行功能损害的改善与症状的改善无明显相关。结论：精神分裂症认知功能损害主要与阴性症状相关，但精神分裂症的大部分认知功能并不随阴性症状改善而改善。

The relationship of schizophrenic symptoms with cognitive function impairment

Objective:To explore the relationship between schizophrenic symptoms and cognitive function impairment. Method:Eighteen negative schizophrenia and 15 positive schizophrenia were treated with clozapine,11 negative schizophrenia and 13 positive schizophrenia were treated with risperidone,negative symptoms,positive symptons,cognitive function were assessed separately before and after treatment. Results:Memory impairment was correlative significantly with both negative and positive symptoms.Attention and executive function impairment were correlative markedly to negative symptoms,not to positive symptoms.Memory was improving with improvement of poverty of thought.Significant correlation was not found between improvement of attention,executive function and improvement of schizophrenic symptoms. Conclusion:Cognitive function of schizophrenia is significantly correlated with negative symptoms.But the great part of schizophrenic cognitive function is not improving with improvement of negative symptoms.