盐酸多塞平乳膏的止痒和抗过敏作用

目的研究盐酸多塞平乳膏(Doxepinhydrochloridecream)的止痒、抗过敏作用。方法观察对4氨基吡啶(4AP)所致小鼠和磷酸组胺所致豚鼠皮肤瘙痒的影响;并观察对醋酸致小鼠腹腔毛细血管通透性及组胺所致大鼠皮肤血管扩张的抑制作用;以2,4-二硝基氯苯(DNCB)致小鼠迟发性过敏反应(DTH)和大鼠同种皮肤被动过敏反应,探讨抗过敏作用。结果小鼠皮肤涂抹盐酸多塞平乳膏(50、125、250mg·kg-1),对4AP所致皮肤的瘙痒有抑制作用;豚鼠皮肤涂抹盐酸多塞平乳膏(10、25、50mg·kg-1),对磷酸组胺所致皮肤瘙痒也有抑制作用。皮肤涂抹盐酸多塞平乳膏(10、25、50mg·kg-1和50、125、250mg·kg-1)可抑制磷酸组胺致大鼠皮肤毛细血管通透性增加和醋酸致小鼠腹腔毛细血管通透性增加。皮肤涂抹盐酸多塞平乳膏(50、125、250mg·kg-1和10、25、50mg·kg-1)可抑制2,4二硝基氯苯致小鼠迟发性变态反应和大鼠同种皮肤过敏反应。结论盐酸多塞平乳膏具有止痒、抑制致炎性物质所致毛细血管通透性增加和对Ⅰ、Ⅳ型变态反应有抑制作用。

The anti-itching and anti-hypersensitivity effects of Doxepin hydrochloride cream

Aim To study the anti-itching and anti-hypersensitivity effects of Doxepin hydrochloride cream. Methods The effects of Doxepin hydrochloride cream on the pruritus of skin in mice due to 4-AP and guineapigs due to histamine phosphate were observed. The inhibitory actions of it on the increase of abdominal cavity capillary permeability in mice due to acetic acid and the angiectasis of skin in rats due to histamine were also observed. Its effects on the delayed-type hypersensitivity (DTH) of mice due to 2, 4-dinitrochlorobenzol (DNCB) and the homologous passive anaphylaxis of skin in rats were used to investigate its anti-hypersensitivity actions. Results The application of Doxepin hydrochloride cream (50, 125, 250 mg·kg -1) on the skin of mice had significant inhibitory actions on the pruritus of skin caused by 4-AP, and the application of Doxepin hydrochloride cream (10, 25, 50 mg·kg -1) on the skin of guinea pigs also had significant inhibitory actions on the pruritus of skin caused by histamine phosphate. The application of Doxepin hydrochloride cream (10,25,50 mg·kg -1 and 50,125,250 mg·kg -1) on skin inhibited the increase of skin capillary permeability in rats caused by histamine phosphate and the increase of abdominal cavity capillary permeability in mice caused by acetic acid. The application of Doxepin hydrochloride cream (50, 125, 250 mg·kg -1 and 10, 25, 50 mg·kg -1) on skin also significantly inhibited the delayed-type hypersensitivity in mice due to 2, 4-dinitrochlorobenzol and the homogeneous cutaneous anaphylaxis in rats. Conclusions Doxepin hydrochloride cream can relieve itching,inhibit the increase of capillary permeability caused by inflammatory substances. It also has significant inhibitory actions on TypeⅠ and Type Ⅳ allergic reactions.