抗甲状腺药物致肝损害42例临床分析

目的 :探讨抗甲状腺药物 (ATD)引起肝损害的临床特点、治疗及转归。方法 :对 4 2例因服用ATD致肝损害患者进行回顾性分析。结果 :亚临床肝损害不需停用ATD ,加用保肝药绝大多数 1个月之内治愈 ;显著肝损害者除立即停用ATD外 ,通过保肝、降酶、利胆等综合治疗 ,大多数也可好转或治愈 ,但前者疗效明显高于后者 (P <0 .0 1)。结论 :肝损害可发生于ATD治疗的全过程 ,但绝大多数发生在开始治疗的前 3个月 ,故应常规定期监测肝功能 ,尤其在治疗的前 3个月 ,以避免肝损害的发生。

Clinical analysis of antithyroid drug-induced hepatotoxicity:A report of 42 cases

Objective:To explore the clinical features,treatment and prognosis of antithyroid drug(ATD) induced hepatotoxicity.Methods:Retrospcetive analysis was performed in 42 hyperthyrodism patients with ATD induced hepatotoxicity.Results:Most patients with subclinical ATD induced hepatotoxicity were cured within one month by adding drug of protecting hepatic function,without stoping ATD.Most patients with severe hepatotoxicity were cured or improved by combined therapy and stopping ATD.Conclusions:ATD induced hepatotoxicity can occur in the whole process of ATD therapy,but most frequently at the first 3 months,so hepatic function must be routinely monitored in order to avoid severe hepatotoxicity.