| 铅、镉、铬和锰对小鼠单核-巨噬细胞系统吞噬功能的影响 |
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| 引用本文： | 王家骥,佘素贞.铅、镉、铬和锰对小鼠单核-巨噬细胞系统吞噬功能的影响[J].卫生毒理学杂志,1990(2). |
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| 作者姓名： | 王家骥 佘素贞 |
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| 作者单位： | 安徽医科大学卫生毒理学教研室
(王家骥)，安徽医科大学卫生毒理学教研室(佘素贞) |
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| 摘 要： | 应用小鼠碳粒廓清实验方法研究了铅、镉、铬和锰对单核-巨噬细胞系统(M-PS)吞噬功能的影响。结果显示,小鼠分别连续接触硝酸铅(96mg/kg)、硫酸镉(7mg/kg)和重铬酸钾(5mg/kg)5天后,血中胶体碳粒的廓清速率比对照组明显降低。说明铅、镉和铬对MPS的整体吞噬功能具有免疫毒性作用。
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| 关 键 词： | 碳粒廓清速率 吞噬作用 单核-巨噬细胞系统 重金属 |
Effects of Lead, Cadmium,Chromate and Manganese on the Phagocytic Function of Mononuclear Phagocytic System in Normal Mice |
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| Wang Jiaji,She Suzhen.Effects of Lead, Cadmium,Chromate and Manganese on the Phagocytic Function of Mononuclear Phagocytic System in Normal Mice[J].Journal of Health Toxicology,1990(2). |
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| Authors: | Wang Jiaji She Suzhen |
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| Abstract: | Using the technique for measuring clearance rate of intravascular celleidal carbon, we studied the effects of lead, cadmium, chromate and manganese on the phagocytic function of mononuclear phagocytic system ( MPS ) in normal ICR strain mice.The results showed that in mice exposed to lead nitrate ( 96mg/kg ) , cadmium sulfat; ( 7mg/ kg ) , potassium bichromate ( 5mg/kg ) for 5 days, the clearance rata of intravascular colloidal carbon was decreased significantly as compared with control group. It suggested that Pb. Cd and Cr may inhibit the phagocytic activity of MPS. |
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| Keywords: | Clearance rats of charcoal particles Phagocytosis MPS Heavy metal |
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