| 组胺H_2受体阻断剂对大鼠失血性应激反应时胃功能和溃疡指数的影响 |
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| 引用本文： | 李和泉. 组胺H_2受体阻断剂对大鼠失血性应激反应时胃功能和溃疡指数的影响[J]. 中国病理生理杂志, 1986, 0(2) |
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| 作者姓名： | 李和泉 |
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| 作者单位： | 中国医科大学病理生理学教研室 |
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| 摘 要： | 用反射光谱法,研究了组胺H_2受体阻断剂Famotidine对急性失血大鼠胃粘膜血液量及血氧饱和度的影响。同时观察了胃液量和酸排出量的变化,并计量了溃疡指数。Famotidine(3mg/kg及8mg/kg,iv)对失血前大鼠胃粘膜血液量和血氧饱和度均未见有影响;对失血后胃粘膜血液量和血氧饱和度的降低有明显保护作用,对胃液量和酸排出量均有显著抑制作用,溃疡指数减小。
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| 关 键 词： | 组胺H_2受体阻滞剂 胃粘膜 胃溃疡 |
The effect of histamine H_2 receptor blocker famotidine on the gastric function and ulcer-index in rats of hemorrhagic stress |
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| Li He-Quan. The effect of histamine H_2 receptor blocker famotidine on the gastric function and ulcer-index in rats of hemorrhagic stress[J]. Chinese Journal of Pathophysiology, 1986, 0(2) |
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| Authors: | Li He-Quan |
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| Affiliation: | Li He-Quan Department of Pathophysiology,China Medical University,Shenyang |
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| Abstract: | The effect of a histamine H_2 receptor blocker-famotidine on the changes of blood volume and oxygen saturation in the gastric mucosa of rats under hemorragic stress was studied with reflectance spectrophotometry. The effects of famotidine on the volume of gastric juice and gastric acid excreted and also stress uIceration were studied at the same time. Before hemorrhage, famotidine (3mg. kg~(-1), 8mg.kg~(-1iv)) did not alter the blood volume and oxygen saturation in the gastric mucosa. Under hemorrhagic state, famotidine could prevent the decrease of blood volume and oxygen saturation in the gastric mucosa and decreased the volume of gastric juice and gastric acid secretions, and could also protect the rats from formation of stress ulcer. |
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| Keywords: | Histamine H_2 receptor blockaders Gastric mucosa Stomach ulcer |
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