射频治疗原发性肝癌前后可溶性白细胞介素-2受体和肿瘤坏死因子的变化

目的　研究原发性肝癌患者集束电极射频治疗前后血清可溶性白细胞介素 - 2受体 (SIL - 2 R)和肿瘤坏死因子(TNF)水平的变化及其临床意义。方法　采用 EL ISA双抗体夹心法 ,检测 4 2例原发性肝癌 (HCC)患者集束电极射频治疗前后血清 SIL - 2 R和 TNF的表达水平的改变 ,并与健康对照组比较 ;分析 SIL - 2 R和 TNF与 AFP的相关性。结果　治疗前 HCC患者血清 SIL - 2 R和 TNF水平明显高于对照组 (P<0 .0 1) ;集束电极射频治疗后 1周 ,血清 SIL - 2 R和 TNF水平无明显变化(P>0 .0 5 ) ;治疗后 2周 ,血清 SIL - 2 R和 TNF水平降低 ,与治疗前比较差异有显著性 (P<0 .0 1) ,但仍高于对照组 (P<0 .0 1) ;血清 SIL - 2 R/ TNF水平与 AFP水平不相关。结论　原发性肝癌患者集束电极射频治疗后血清中 SIL - 2 R和 TNF水平下降 ,机体免疫功能增强 ;并可作为早期诊断、病情判断、复发检测的重要指标

CHANGES OF SERUM LEVEL OF SOLUBLE INTERLEUKIN-2 RECEPTOR AND TUMOR NECROSIS FACTOR IN PATIENTS WITH HEPATOCELLULAR CARCINOMA PRE-AND-POST RADIO FREQUENCY ABLATION

Objective To investigate changes of serum level of soluble interleukin 2.Methods The serum level of SIL 2R and TNF were measured with ELISA in 42 patients with HCC pre RFA,post RFA and 20 healthy individuals;the correlativity between the serum level of SIL 2R/TNF and AFP were analysed.Result Mean serum level of SIL 2R and TNF in pre RFA were significantly higher than those in control( P <0.01);and compared with those in pre RFA,they were significantly decreased in post RFA( P <0.01);There is no correlativity betwwen SIL 2R/TNF and AFP.Conclusion SIL 2R and TNF of HCC after RFA are decrease,and the immunity is increase;SIL 2R/TNF is a important index for early diagnosis,judgement of disease progress and minitoring of recurrence in patients with HCC.