Partin表对前列腺癌患者术后临床资料预测意义的验证研究

目的验证Partin表对预测我国前列腺癌患者预后的准确性。方法回顾性分析2008年1月~2011年1月在解放军总医院行前列腺癌根治术患者的临床资料,符合Partin表入组标准的收集前列腺特异抗原(PSA)、Gleason评分、临床分期、病理分期资料,术前资料通过Partin表推断与病理分期实际结果比较,利用受试者工作特征曲线(ROC)评估Partin表的准确性。结果本研究共收集符合标准病例97例,本组资料与Partin表基础人群相比较,年龄、PSA、Gleason评分高,临床分期晚。肿瘤器官局限性病例比例类似(73.2%vs 73.4%);包膜侵犯病例比重略低于研究基础人群(14.4%vs 22.3%);精囊侵犯率两者比例接近(5.2%vs 3.0%);淋巴结转移率明显高于研究基础人群(7.2%vs 1.2%)。利用ROC曲线计算器官局限、包膜侵犯、精囊侵犯、淋巴结转移的曲线下面积,分别为0.782、0.637、0.817及0.570。结论 Partin表对前列腺肿瘤的局限性以及精囊侵犯有一定的预测意义,而对包膜侵犯诊断价值不高,对淋巴结转移诊断效果不佳。

Partin tables for prostate cancer patients with postoperative clinical date forecast validation studies

Objective To verify Partin Tables′accuracy in predicting the prognosis of Chinese patients with prostate neoplasm.Methods Patients who underwent radical prostatectomy from January 2008 to December 2011 and tallied with inclusion criteria were analyzed retrospectively. Data including PSA,Gleason score,clinical and pathological stage were analyzed. Calculated pathological stage and acutal pathological stage were compared using Partin Tables,and the accuracy of the Partin Tables for prognosis was evaluated using receiver operation curve. Results 97 cases were collected according to the standard of Partin tablesin this study.Age（67 ± 7 years old vs 57 ± 6 years old）,PSA,Gleason score,clinical staging of our cohort were higher than those of Partin Tables cohort. The ratio of organ confined disease（73.2% vs 73.4%） and seminal vesicle（5.2% vs 3.0%） of the two groups were similar;the ratio of capsular penetration（14.4% vs 22.3%） was slightly lower in our cohort; the radio of lymph node involvement（7.2% vs 1.2%）was much higher than Partin Tables cohort. The area of curve of ROC was 0.782 、0.637、0.817 and 0.570 respectively. Conclusion For our cohort Partin Tables can predict organ confined disease and seminal vesicle,and diagnostic value is not high for the capsular penetration, judge of lymph node metastasis effect is not acceptable.