白血病抑制因子对异位妊娠早期诊断的价值评估

目的:检测血清中白血病抑制因子(Leukemia inhibitory factor,LIF)、LIFR、IL-1α、TNF-α水平,评估其对早期异位妊娠的诊断价值。方法:选取异位妊娠患者60例作为观察组;正常宫内妊娠20例作为对照组。采用ELISA法测血清LTF、LIFR、IL-1α、TNF-α水平。结果:①血清LIF水平在异位妊娠组及正常早孕组分别为(5·26±0·51)pg/ml及(5·88±0·26)pg/ml;血清LIFR水平在异位妊娠组及正常早孕组分别为(3·82±1·6)pg/ml及(2·95±1·70)pg/ml。异位妊娠组与正常早孕组血清LIF及LIFR水平分别比较,差异均有统计学意义(P<0·01)。异位妊娠组血LIF较正常早孕组低,而LIFR则较正常早孕高。②血清TNF-α水平在异位妊娠组及正常早孕组分别为(66·71±9·31)pg/ml及(54·4±8·36)pg/ml;血清IL-1α水平在异位妊娠组及正常早孕组分别为(0·29±0·20)pg/ml及(0·28±0·13)pg/ml。异位妊娠组与正常早孕组血清TNF-α及IL-1α水平分别比较,差异均有统计学意义(P<0·01)。异位妊娠组血TNF-α、IL-1α较正常早孕组高。结论:检测血清LIF水平有助于鉴别异常宫内妊娠与异位妊娠;联合检测LIF、LIFR、TNF-α、IL-1α可作为临床早期诊断异位妊娠高效、有力、敏感的指标。

The evaluation of sera levels of LIF in diagnosis of early eetopie pregnancy

Objective:To evaluate the value of LIF, LIFR, IL-1αand TNF-αlevels in early diagnosis of ectopic pregnancy.Methods:The sera levels of LIF, LIFR, IL-1αand TNF-α were measured by ELISA respectively. 60 specimens of ectopic pregnancy were study group (EP),and 20 specimens of normal pregnancy were normal control group (NIUP) respectively.Results:(1) In EP and NIUP group the level of LIF was (5.26±0.51)pg/ml and (5.88±0.26)pg/ml respectively. And the level of LIFR was (3.82±1.6)pg/ml and (2.95±1.70)pg/ml respectively;There were significantly diferent between NIUP and EP group (P<0.01). The level of LIF in the the EP was obviously reduced,while the level of LIFR was markedly enhanced. (2) In EP and NIUP group the level of TNF-α was (66.71±9.31)pg/ml and (54.4±8.36)pg/ml respectively;And the level of IL-1α was (0.29±0.20)pg/ml and (0.28±0.13)pg/ml respectively;There were significantly difference between NIUP and EP group(P<0.01). The level of IL-1αand TNF-αin the the EP was obviously enhanced.Conclusion:LIF level is helpful to distinguish normal pregnancy and ectopic pregnancy. LIF, LIFR, IL-1αand TNF-αwould be very valuable for the clinical diagnosis of early ectopic pregnancy.