硒拮抗砷致大鼠血脂谱改变的效应特征研究

目的：明确硒拮抗砷致大鼠血脂谱变化的可行性及剂量特征。方法：将受试动物随机分为阴性对照组、砷组、硒组及胂＋硒组（以测试物的LD50为剂量划分依据）。染毒后测定血中血脂含量的变化。结果：与阴性对照组比较，1／5LD50As组血中总胆固醇、甘油三酯和高密度脂蛋白含量均有显著性差异（P＜0．05），总胆固醇和甘油三酯呈下降趋势，高密度脂蛋白呈上升趋势：与1／5LD50As相比，1／5LD50As＋1／160LD50Se组血中甘油三酯含量有显著性差异（P＜0．05）；1／5LD50As＋1／120LD50Se组血中总胆固醇、甘油三酯含量有显著性差异（P＜0．05）；1／5LD50As＋1／80LD50Se组血中总胆固醇、甘油三酯和高密度脂蛋白含量均有显著性差异（P＜0．05）。结论：结果提示，砷可致大鼠血脂谱的改变，硒对其具有拮抗作用，且以1／80LD50Se组拮抗效果较好。

Antagonistic effect of selenium on arsenic-induced changes in blood lipids spectrum in rat

Objective To clarify the feasibility of selenium against arsenic-induced blood lipids changes in rat and its dose range characteristics.Methods The rats were randomly divided into control,arsenic,selenium,arsenic and selenium in combination,respetively.After various treatments,the blood lipids were determined.Results In comparison with the levels of total cholesterol(TC),triglyceride(TG) and high-density lipoprotein(HDL) in control group,there was a significant decrease in TC and TG and a rise in HDL in 1/5 LD 50 arsenic group.Relative to those in 1/5 LD 50 arsenic group,there was a significant difference in TG in 1/5 LD 50 As and 1/160 LD 50 Se group(P<0 05),TC and TG in 1/5 LD 50 As and 1/120 LD 50 Se group(P<0 05).TC,TG and HDL in 1/5 LD 50 As and 1/80 LD 50 Se group(P<0 05),respectively.Conclusion Arsenic could induce a change in blood lipids spectrum in rat and that selenium could combat against this change. 1/80 LD 50 Se might be the optimal dose for the effect.