冠心病患者血浆胎盘生长因子水平的研究

目的 比较冠心病患者和正常人血浆中胎盘生长因子(PlGF)水平,并评价血浆PlGF水平与冠脉病变程度的相关性.方法 对48例冠心病患者(均接受冠脉造影确诊,冠心病组)及28例健康志愿者(对照组)抽静脉血测定血浆PlGF水平(采用人PlGF定量试剂盒),并进行组间比较.同时记录冠心病患者冠脉病变支数及Gensini冠脉病变积分,分别与血浆PlGF水平进行相关性分析.结果 冠心病组血浆PlGF水平高于对照组(9.16±4.09) ng/L vs (3.64±1.90) ng/L,P＜0.01].血浆PlGF水平与冠脉病变支数(r=0.64,P＜0.05)和Gensini冠脉病变积分(r=0.78,P＜0.01)均呈正相关.结论 检测血浆PlGF水平可能有助于冠心病的早期诊断和冠脉病变程度的评估.

Detection of Plasma Level of Placental Growth Factor from Patients with Coronary Artery Disease

OBJECTIVE: To investigate the plasma placental growth factor (P1GF) level of patients with coronary artery disease (CAD), and the correlation between plasma P1GF level and coronary lesion severity. METHODS: The study population consisted of 48 patients with CAD (proved by angiography, CAD group) and 28 normal controls (control group). Plasma P1GF was determined by an enzyme linked immunosorbent assay (ELISA). The lesion severity of coronary artery was assessed by Gensini coronary scoring system, the correlation between plasma P1GF level and coronary lesion severity was evaluated. RESULTS: The plasma PIGF level in CAD group was significantly higher than that in the control group C(9. 16+/-4. 09) ng/L vs (3. 64+/-1. 90) ng/L, P< 0. 01). A significant positive correlation was found between coronary lesion severity score and plasma P1GF level (r=0. 78, P<0. 01). CONCLUSION: The detection of plasma PIGF may be helpful to the early diagnosis of CAD and the evaluation of coronary lesion severity.