Synthesis and characterization of 2-(4-((1-alkyl or aryl-1H-1,2,3-triazol-4-yl)methoxy)phenyl)naphtho[1,2-d]oxazoles for protein tyrosine phosphatase 1B inhibitory activity |
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| Authors: | Sridhar Madabhushi Narsaiah Chinthala Abhinav Kanwal Gagandeep Kaur Sanjay K. Banerjee |
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| Affiliation: | 1. Fluoroorganics Division, Indian Institute of Chemical Technology, Hyderabad, 500607, India
2. Pharmacology Division, Indian Institute of Chemical Technology, Hyderabad, 500607, India
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| Abstract: | 2-(4-((1-Alkyl/aryl-1H-1,2,3-triazol-4-yl)methoxy)phenyl)naphtho[1,2-d] were prepared and evaluated as protein tyrosine phosphatase 1B (PTP1B) inhibitors. In this study, two new compounds with potent PTP1B inhibitory activity were identified. |
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