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New aminoadamantane derivatives with antiproliferative activity |
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| Authors: | Ioannis Papanastasiou Andrew Tsotinis Nicolas Kolocouris Spyros P. Nikas Alexandre Vamvakides |
| Affiliation: | 1. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Athens, Panepistimioupoli-Zografou, 157 71, Athens, Greece 2. Center for Drug Discovery, Northeastern University, 116 Mugar Life Sciences Building, 360 Huntington Avenue, Boston, MA, 02115, USA 3. Institute of Organic and Pharmaceutical Chemistry, National Hellenic Research Foundation, 48 Vass. Constantinou, 116 35, Athens, Greece 4. Anavex Life Sciences, 27 Marathonos Avenue, 153 51, Pallini, Athens, Greece |
| Abstract: | 1-Benzyl-2-aminoadamantanes 2a–c, conformationally constrained aminoadamantanes 3a, b and 4 and diaminoadamantanes derivatives 5a–c, 6a–c were synthesized and tested as antiproliferative agents. The in vitro biological evaluation showed a significant difference in activity between 1-phenyl and 1-benzyl derivatives. |
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