Synthesis and biological evaluation of pyrrole-2-carboxamide derivatives: oroidin analogues |
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| Authors: | Balaram S Takale Neha V Desai Afsar Ali Siddiki Hemchandra K Chaudhari Vikas N Telvekar |
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| Institution: | 1. Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Matunga, Mumbai, 400 019, India
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| Abstract: | The reaction of pyrrole or dibromopyrrole-2-trichloroacetone with various amines results in the series of novel pyrrole-2-carboxamide bearing aromatic heterocycle or aryl or alkyl groups. Synthesized molecules were evaluated for their in vitro antibacterial activities. Most of the compounds exhibited potent activity against both Gram-positive and negative pathogens. |
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