单纯性肥胖青少年血清内脂素水平及其与年龄和高密度脂蛋白胆固醇的关系

目的 检测单纯性肥胖及正常青少年血清内脂素水平,探讨其与年龄、体重指数(BMI)、脂联素、瘦素、血脂、血糖及胰岛素水平的关系.方法 研究对象共148名,其中单纯性肥胖症青少年72例,正常对照76名.采用放射免疫分析法、酶法测定两组青少年的空腹血清内脂素、脂联素、瘦素、睾酮、甘油三酯、总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇(HDL-C)等.肥胖组青少年均做口服葡萄糖耐量试验(OGTF),计算胰岛素抵抗指数(HOMA-IR)、胰岛素敏感指数(ISI)和早期胰岛素分泌指数(EISI).结果 肥胖组血清内脂素水平显著高于正常对照组[(37.65±18.28 vs 29.35±12.10) μg/L,P<0.01].正常对照组血清内脂素水平与人体测量指数及脂质参数之间无任何相关性,而肥胖组血清内脂素与年龄、EISI和Tanner分期呈负相关,与血清HDL-C水平呈正相关.并且在校正年龄、性别、体重指数后,内脂素水平与年龄及HDL-C水平仍然呈显著相关(g<0.05).结论 在中国青少年人群中,血清内脂素随年龄增长而下降,且可能参与体内HDL-C代谢的调控.

Association of visfatin with age and high-density lipoprotein-cholesterol in obese adolescents

Objective To examine the impact of adolescent obesity on circulating visfatin levels, and to analyze the relationship between visfatin and anthropometric indices, insulin sensitivity, and blood lipids in Chinese adolescents (11-18 years). Methods Serum visfatin, adiponectin and lepfin were measured by RIA in 76 nonobese and 72 obese adolescents, and their total cholesterol, triglyceride, high-density lipoprotein-cholesterol (HDL-C) and low-density hpoprotein cholesterol were analyzed with enzymatic methods. OGTT was performed according to the World Health Organization standard procedure in obese adolescents, and homeostasis model assessment of insulin resistance (HOMA-IR), insulin sensitivity index (ISI) and early insulin secretion index (EISI) were calculated. Results The serum visfatin level was significantly higher in obese subjects than in non-obese subjects [(37.65±18.28 vs 29.35±12.10) μg/L, P<0.01]. There were no significant correlations between the serum visfatin concentration and the anthropometrie indices or the lipid parameters in the non-obese group. However, visfatin levels were negatively correlated with age, Tanner stage and EISI, and positively correlated with HDL-C in the obese adolescents. These relationships, except that for EISI and Tanner stage,remained significant (P<0.05) after adjustment for age, gender, and body mass index. Moreover, unlike adiponectin and leptin, visfatin concentration was not correlated with testosterone in non-obese and obese boys.Conclusion Visfatin levels decrease with age and may be related to the HDL-C metabohsm in Chinese obese adolescents.