| Fractalkine及其受体CX3CR1与脑血管病 |
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| 引用本文： | 吴丽娥,乌兰.Fractalkine及其受体CX3CR1与脑血管病[J].国际脑血管病杂志,2010,18(2). |
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| 作者姓名： | 吴丽娥 乌兰 |
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| 作者单位： | 包头医学院第一附属医院神经内科,014010 |
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| 摘 要： | Fractalkine是趋化因子家族的新成员,以膜结合形式和可溶性形式存在,兼有黏附分子和趋化因子的活性.CX3CR1是其特异性受体,二者在神经系统的诸多疾病中均有表达.目前,fractalkine其受体CX3CR1的基因多态性与脑血管病的研究,主要涉及脑血管病的危险因素、脑缺血再灌注及骨髓干细胞移植等方面,有望成为临床治疗的新靶点.
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| 关 键 词： | 脑血管障碍 脑缺血 再灌注损伤 趋化因子 CX3C 受体 细胞因子 多态现象 遗传 |
Fractalkine and its receptor CX3 CR1 and cerebrovascular diseases |
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| WU Li-e,WU Lan.Fractalkine and its receptor CX3 CR1 and cerebrovascular diseases[J].International Journal of Cerebrovascular Diseases,2010,18(2). |
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| Authors: | WU Li-e WU Lan |
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| Abstract: | Fractalkine is a new member of chemokine family, which exists in membrane-boundd form and soluble form. It has both adhesion molecular and chemokine activities. CX3 CR1 is its specific receptor. Both of them were expressed in many diseases of the nervous system. At present, fractalkine and its receptor CX3CR1 polymorphism and the research of cerebrovascular diseases mainly involve in the risk factors for cerebrovascular diseases, cerebral ischemia-reperfusion and bone marrow stem cell transplantion, which are expected to become a new target for clinical treatment. |
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| Keywords: | Cerebrovascular disorders Brain ischemia Reperfusion injury Chemokines CX3C Receptors cytokine Polymorphism genetic |
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