几种药物对大鼠过敏性气道炎症的抑制作用

在Sprague-Dawley大鼠过敏性气道炎症模型上观察不同药物的抗炎作用。ip地塞米松(0.5 mg·kg^-1)，粉防己碱(30 mg·kg^-1)以及非肽类神经速激肽受体拮抗剂CP-96345和SR-48968(各1 mg·kg^-1)，每日2次，连续 3 d，可抑制卵白蛋白1 mg致敏大鼠吸入抗原后6 h或24 h肺灌洗液中的白细胞数量增多，明显减轻细支气管和小血管周围嗜酸性细胞浸润及管壁水肿等炎症状况。结果证明大鼠模型可以作为评价平喘药作用的工具，并提示速激肽参与气道过敏性炎症。

Effect of various drugs on airway allergic inflammation in Sprague-Dawley rats

The anti-inflammatory effects of various drugs were observed in a Sprague- Dawley (SD) rat model of airway allergic inflammation. Intraperitoneal injections of dexamethasone (0.5 mg·kg^-1), tetrandrine (30 mg ·kg^-1) and a combination of nonpeptide tachykinin receptor antagonists, CP- 96345 and SR-48968 (1 mg·kg^-1, respectively), twice a day for 3 d, significantly decreased the ovalbumin (OA, 1 mg) aerosol-induced increases in leukocyte numbers in the bronchoalveolar lavage fluid, edema of airway walls, and infiltration of eosinophils around the bronchioles and vessels 6 and 24 h after inhalation in the OA -sensitized SD rats. This result indicates the usefulness of SD rat allergic air way inflammation as a model for evaluation of the anti inflammatory effects of anti asthmatic drugs, and the involvement of endogenous tachykinins in the alle rgic airway inflammation.