多巴胺受体阻断剂对小鼠耐缺氧能力和体温的影响

多巴胺受体阻断剂对小鼠耐缺氧能力和体温的影响１沈德莉２陈蔚芸邱常青王和平３（江西医学院药理学教研室，３江西医院，南昌３３０００６）氯丙嗪（ｃｈｌｏｒｐｒｏｍａｚｉｎｅ，ＣＰＺ），氟哌啶醇（ｈａｌｏｐｅｒｉｄｏｌ，Ｈａｌ）均为多巴胺（ＤＡ）受体阻断剂，...

Effects of dopamine receptor antagonists on capability of resisting anoxia and body temperature in mice

The protective effects of haloperidol (Hal 1 mg·kg^-1), l-stepholidine (SPD 10 mg·kg^-1) and chlorpromazine (CPZ 10 mg·kg^-1) against anoxia in mice were studied. At the ambient temperature 27℃ and 5℃, Hal, SPD and CPZ ip lowered body temperature of mice. At the ambient temperature 27 ℃, Hal, SPD ip reduced the oxygen consumption (39±9 and 46±5 mL·min^-1·kg^-1 vs 63±7 mL·min^-1·kg^-1), lowered the oxygen concentration at death point (1.1±0.9% and 2.7±1.0% vs 3.7±1.4%), enhanced the capability of resisting anoxia and prolonged the survival time (58±9 and 40±9 min vs 31±5 min)of mice in closed containers. At the ambient temperature 5℃, CPZ ip reduced the oxygen consumption (40±11 mL·min^-1·kg^-1 vs 61±12 mL·min^-1·kg^-1), prolonged the survival time (38±4 min vs 33±6 min) of mice but at the ambient temperature 27℃ or 5℃, CPZ enhanced the oxygen concentration at death point (5.1±1.2% vs 3.7±1.4% and 7.7±2.4% vs 2.1±1.0%). The results indicate that Hal, SPD protect against anoxia at 27℃. CPZ protects against at 5℃.