| 槲皮素对糖尿病大鼠周围神经病变的保护作用 |
| |
| 引用本文： | 王新嘉 何国芬貟克明李贵民张 辉. 槲皮素对糖尿病大鼠周围神经病变的保护作用[J]. 中国药理学与毒理学杂志, 1997, 11(3): 233-234 |
| |
| 作者姓名： | 王新嘉 何国芬貟克明李贵民张 辉 |
| |
| 作者单位： | 山西医科大学第二附属医院内科，山西医科大学第一附属医院内分泌科，山西医科大学法医系 |
| |
| 摘 要： | 槲皮素对糖尿病大鼠周围神经病变的保护作用１王新嘉何国芬２克明３李贵民３张辉（山西医科大学第二附属医院内科，太原０３０００１）周围神经组织的非酶糖基化与糖尿病神经病变的发生有关［１］，最近发现抗氧化剂槲皮素（ｑｕｅｒｃｅｔｉｎ）对组织蛋白非酶糖基化有...
|
| 关 键 词： | 糖尿病 实验性；神经传导；非酶糖基化；槲皮素；氨基胍 |
| 收稿时间： | 1996-04-03 |
Protective effect of quercetin on pathological change in eripheral nerve in diabetic rats |
| |
| WANG Xin Jia,HE Guo Fen,YUN Ke Ming,LI Gui Min,ZHANG Hui. Protective effect of quercetin on pathological change in eripheral nerve in diabetic rats[J]. Chinese Journal of Pharmacology and Toxicology, 1997, 11(3): 233-234 |
| |
| Authors: | WANG Xin Jia HE Guo Fen YUN Ke Ming LI Gui Min ZHANG Hui |
| |
| Affiliation: | (Deparment of Internal Medicine, The Second Affiliated Hospital, Shanxi Medical University, Taiyuan 030001) |
| |
| Abstract: | In order to study the protective role of quercetin on diabetic neuropathy in streptozotocin-induced diabetic rats, the motor nerve conduction velocity (MNCV) and the content of advanced glycosylation end products (AGEP) in sciatic nerve were examined, in comparing with the effect of aminoguanidine (50 mg·kg-1·d-1 for 16 wk, ig). Quercetin (100 mg·kg-1·d-1 for 16 wk, ig) treatment significantly lowered the content of AGEP and improved the MNCV in the sciatic nerve. These findings suggest that quercetin may have a similar protective role in diabetic neuropathy as aminoguanidine. |
| |
| Keywords: | diabetes mellitus experimental neural conduction nonenzymatic glycosylation quercetin aminoguanidine |
| 本文献已被 CNKI 维普 等数据库收录！ |
| 点击此处可从《中国药理学与毒理学杂志》浏览原始摘要信息 |
|
点击此处可从《中国药理学与毒理学杂志》下载全文 |
