| 肝再生刺激物质对大鼠实验性肝衰竭的肝再生与形态学的影响 |
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| 引用本文： | 姚志强,刘健.肝再生刺激物质对大鼠实验性肝衰竭的肝再生与形态学的影响[J].第四军医大学学报,1992,13(2):96-99. |
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| 作者姓名： | 姚志强 刘健 |
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| 作者单位： | 唐都医院传染病科
(姚志强，杨为松，张文彬，陈勇)，唐都医院电镜室(刘健) |
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| 摘 要： |
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| 关 键 词： | 肝衰竭 肝再生 生长因子 |
Effect of human hepatic stimulator substance on liver regeneration and morphologic changes in experimental liver failure in rats |
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| YAO Zhi-Qiang YANG Wei-Song,ZHANG Wen Bin,CHEN Yong and Liu Jian.Effect of human hepatic stimulator substance on liver regeneration and morphologic changes in experimental liver failure in rats[J].Journal of the Fourth Military Medical University,1992,13(2):96-99. |
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| Authors: | YAO Zhi-Qiang YANG Wei-Song ZHANG Wen Bin CHEN Yong and Liu Jian |
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| Institution: | YAO Zhi-Qiang YANG Wei-Song,ZHANG Wen Bin,CHEN Yong and Liu Jian Department of Infectious Diseases,Tangdu Hospital Department of Electronic Microscope |
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| Abstract: | The treatment of human hepatic stimulator substance for the acute liver failure induced by D-galactosamine in rats was evaluated. Thirty rats administrated with D-GL (1.2 gAg) were divided into 2 groups. The rats were treated with hHSS or saline 2 hours before being poisoned. It was demonstrated that the incorporation of 3H-TdR into hepatic DNA in the HSS group significantly increased compared with the controls, especially at 48 hours alter administration of D-GL. Autoradiograms showed that 3H-TdR was specifically incorporated into hepatocytes neclei. The morphologic changes showed that the damages to cellular and subcellular structures seen in the liver of HSS treated rats were much alleviated and rapidly repaired. The results suggested that HSS might be a new hepatic growth factor that could prevent liver from deterioration and promote hepatocyte regeneration. |
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| Keywords: | liver failure hepatic regeneration growth factor microscopy electron auloradiograph |
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