| 镇痛药研究进展 |
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| 引用本文： | 聂红.镇痛药研究进展[J].中国新药杂志,2003,12(12):984-987. |
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| 作者姓名： | 聂红 |
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| 作者单位： | 暨南大学药学院药理教研室,广州,510632 |
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| 基金项目： | 博士后科学基金(中博基[2001]5号) |
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| 摘 要： | 镇痛药研究引入了细胞及分子生物学的最新研究手段和方法，并从神经激肽类阻滞剂、N-甲基-D-天门冬氨酸(N—methyl—D—aspartate，NMDA)受体阻滞剂、腺苷激酶抑制剂、脑啡肽分解酶抑制剂、降钙素基因相关肽(Calcitonin gene—related peptide，CGRP)受体阻滞剂、镇痛复合制剂等方面拓宽了镇痛药研究的思路。新建立的研究模型包括培养脊髓背根神经节神经元模型及吞咽反应模型。
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| 关 键 词： | 镇痛药 神经激肽类阻滞剂 N-甲基-D-天门冬氨酸受体阻滞剂 |
| 文章编号： | 1003-3734(2003)12-0984-04 |
New development of analgesic |
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| NIE Hong.New development of analgesic[J].Chinese Journal of New Drugs,2003,12(12):984-987. |
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| Authors: | NIE Hong |
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| Abstract: | The developments of pain and mechanism research in recent years were reviewed in this paper. The new methods of cells and molecular biology are used in analgesic research and widen the thinking of analgesic by neurokinins antagonist, N-methyl-D-aspartate (NMDA) receptor antagonist, adenosine kinase inhibitor, enkephalin catabolism inhibitors, calcitonin gene-related peptide (CGRP) receptor antagonist and the coadministration of compounds with morphine. The new-established model included the model of cultured dorsal root ganglion neurons and swallowing respond model. |
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| Keywords: | analgesic neurokinins antagonist N-methyl-D-aspartate receptor antagonist |
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