| CDK4在膀胱移行细胞癌中的表达及其临床意义 |
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| 引用本文： | 陈晓波,谭建明,陈坚.CDK4在膀胱移行细胞癌中的表达及其临床意义[J].实用医学杂志,2006,22(4):380-381. |
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| 作者姓名： | 陈晓波 谭建明 陈坚 |
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| 作者单位： | 1. 200080,上海交通大学附属第一人民医院肾移植科
2. 530021,南宁市,广西医科大学第一附属医院泌尿外科 |
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| 摘 要： | 目的:探讨CDK4蛋白在膀胱移行细胞癌(BTCC)中的表达及其临床意义。方法:采用免疫组化方法,测定10例正常膀胱黏膜及40例BTCC标本中的CDK4蛋白的表达。结果:CDK4蛋白在正常膀胱黏膜和BTCC中的阳性表达率分别为0.00%、52.50%(P<0.05)。CDK4蛋白在G1、G2、G3中的阳性表达率依次为36.84%、61.54%、75.00%,差异无显著性(P>0.05);在Tis～T1中CDK4阳性表达率为40.00%,明显低于T2～T4中的73.33%(P<0.05)。结论:CDK4的过度表达可能在BTCC的进展中发挥了重要作用,CDK4可成为一种新的预后判断的参考指标。
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| 关 键 词： | 癌 移行细胞 膀胱肿瘤 免疫组织化学 细胞周期蛋白质依赖激酶类 CDK4蛋白 |
| 收稿时间： | 2005-11-01 |
| 修稿时间： | 2005-11-01 |
Expression of CDK4 in human bladder transitional cell carcinoma and its clinical significance |
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| CHEN Xiao-bo,TAN Jian-ming,CHEN Jian.Expression of CDK4 in human bladder transitional cell carcinoma and its clinical significance[J].The Journal of Practical Medicine,2006,22(4):380-381. |
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| Authors: | CHEN Xiao-bo TAN Jian-ming CHEN Jian |
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| Institution: | Department of Renal Transplantation and Urology, the First Affiliated Hospital, Shanghai Jiao Tong University, Shanghai 200080, China |
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| Abstract: | Objective To investigate the expression and clinical significance of CDK4 protein in bladder transitional cell carcinoma ( BTCC ). Methods CDK4 protein expression of 40 BTCC and 10 normal bladder tissues were analysed by immunohistochemistry. Results The positive rates of CDK4 were 52.50%in BTCC and 0.00%in normal bladder tissues (P< 0.05).The positive rates of CDK4 in G1,G2 and G3 were 36.84%, 61.54%, 75.00%,respectively;and no statistically significant difference among the three groups(P >0.05).The positi... |
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| Keywords: | Carcinoma transitional cell Bladder neoplasms Immunohistochemistry Cyclin-dependent kinases CDK4 protein |
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