tPSA、f／tPSA在不同数值范围时tPSA、fPSA、f／tPSA与前列腺癌相关性研究

目的研究tPSA、f／tPSA在不同数值范围时tPSA、fPSA、f／tPSA与前列腺癌的相关性。方法选择男性患者385人予血清tPSA、fPSA、f／tPSA测定，并行TRUS引导前列腺活检术或TuRP术获得病理结果，对不同tPSA、f／tPSA范围内tPSA、fPSA、f／tPSA与前列腺癌作相关性分析。结果当tPSA≤4ng／ml时，tPSA、fPSA、f／tPSA均与PCa无显著相关性（P〉0．05）；当4〈tPSA≤20ng／ml时，f／tPSA与PCa有显著相关性（P〈0．05），而tPSA、fPSA均与PCa无显著相关性（P〉0．05）：当tPSAt〉20ng／ml时，tPSA与PCa有显著相关性（P〈0．05），而fPSA、f／tPSA则与PCa无显著相关性（P〉0．05）。当f／tPSA〈0．1时。tPSA与PCa有显著相关性（P〈0．05），而fPSA、f／tPSA则与PCa无显著相关性（P〉0．05）；当f／tPSAi〉0．1时，tPSA、fPSA均与PCa有显著相关性（尸〈0．05），而f／tPSA与PCa无显著相关性（P〉0．05）。结论tPSA、f／tPSA在不同数值范围时tPSA、fPSA、f／tPSA与PCa的相关性是存在差异的，应根据不同tPSA、f／tPSA的范围选择相关性显著的指标进行分析。

Research on the Correlation between tPSA, fPSA, f/tPSA and Prostate Cancer in Different Range of tPSA, f/tPSA

Objective To study the correlation between tPSA, fPSA, f/tPSA and prostate cancer in different range of tPSA, f/tPSA. Methods Levels of serums tPSA, fPSA, f/tPSA were measured in a total of 385 male patients. TRUS guided systematic prostate biopsy or TURP were performed and biopsy results were acquired to analyse the correlation between tPSA, fPSA, f/tPSA and prostate cancer in different range of tPSA,f/tPSA. Results TPSA, tPSA and f/tPSA had no correlation noticeably with PCa when tPSA was less than 4 ng/ml（P 〉 0.05）. When tPSA was within 4- 20 ng/ml, f/tPSA had correlation noticeably with PCa（P 〈 0.05）, but not for tPSA and fPSA（P 〉 0.05）. When tPSA was more than 20 ng/ml, tPSA had correlation noticeably with PCa（P 〈 0.05）, but not for tPSA and f/tPSA（P 〉 0.05）. When f/tPSA was less than 0.1, tPSA had correlation noticeably with PCa（P 〈 0.05）, but not for fPSA and f/tPSA（P 〉 0.05）. When f/tPSA was more than 0.1, tPSA and IPSA all had correlation noticeably with PCa（P 〈 0.05）, but not for f/tPSA（P 〉 0.05）. Conclusions It has different correlation between tPSA, fPSA, f/tPSA and prostate cancer in different range of tPSA, f/tPSA. We should choose notable hades to analyse in different range oftPSA, f/tPSA.