多囊卵巢综合征患者用二甲双胍治疗后血管内皮功能变化

目的 探讨多囊卵巢综合征(PCOS)患者用二甲双胍治疗后血管内皮功能变化.方法 PEOS患者30例,用二甲双胍500 mg,每天3次,连续用6个月.与对照组比较,测定血流调节右肱动脉扩张内径,测定血内皮素-1、胰岛素、睾酮、血糖、血脂等;测量腰臀比和体重指数(BMI).结果 研究组用二甲双胍治疗后WHR、BMI和内皮素-1,与治疗前相比差异无统计学意义(P＞0.05);肱动脉内径变化增大、LH/FSH减小、T下降、胰岛素下降、HOMA-IR下降、TG下降、HDL增高、LDL下降,与治疗前相比差异有统计学意义(P＜0.05).研究组治疗后与对照组相比较,WHR、BMI、内皮素-1、肱动脉内径变化、LH/FSH、T、胰岛素、HOMA-IR、TG、LDL无明显变化(P＞0.05);HDL升高,与对照组比较差异有统计学意义(P＜0.05).结论 PCOS患者存在血管内皮功能的损伤和胰岛素抵抗,用二甲双胍治疗后,血管内皮功能和胰岛素抵抗得到改善.

Effect of metformin on endothelial function in women with polycystic ovary syndrome

Objective To evaluate the effect of metformin on endothelial function in women with polycystic ovary syndrome.Methods 30 women with PCOS were enrolled.Metformin were taken 500mg three times a day contiguously using 3 months.Before and after treatment flow-mediated EDD function and other clinical metabolic parameters,such as serum endothelin-1,insulin,testosterone,glucose,lipid,waist-hip ratio,body mass index.Results After the treatment of metformin in study group,WHR,BMI and endothelin-1 have no significant difference compared with before the treatment(P＞0.05).But the changes of brachial artery diameter and HDL were increasing and LH/FSH,T,insulin,HOMA-IR,TG and LDL were significant decreasing after the treatment in study group compared with before the treatment(P＜0.05).There was no significant difference in WHR,BMI,endothelin-1,the changes of brachial artery diameter,LH/FSH,T,insulin,HOMA-IR,TG and LDL between the study group after the treatment with the control group.Meanwhile,HDL were significant increasing in the study group after the treatment compared with the control group(P＜0.05).Conclusion There are impaired endothelial function and insulin resistance in women with PCOS.After the treatment with metrormin,the endothelial function and insulin resistance could be improved.