Antiplasmodial and cytotoxic activities of medicinal plants traditionally used in the village of Kiohima, Uganda |
| |
Authors: | Lacroix Damien Prado Soizic Kamoga Dennis Kasenene John Namukobe Jane Krief Sabrina Dumontet Vincent Mouray Elisabeth Bodo Bernard Brunois Florence |
| |
Institution: | a Molécules de Communication et Adaptation des Micro-Organismes, FRE 3206 CNRS/MNHN, Muséum National d’Histoire Naturelle, 57 rue Cuvier, 75005 Paris, France b Department of Botany, P.O. Box 7062, Makerere University, Kampala, Uganda c Chemistry Department, Makerere University, Box 7062, Kampala, Uganda d Eco-Anthropologie et Ethnobiologie, MNHN-CNRS, 43 rue Buffon, 75005 Paris, France e Centre de recherche de Gif, Institut de Chimie des Substances Naturelles, CNRS - Avenue de la Terrasse 91198 Gif-sur-Yvette, France f Laboratoire d’Anthropologie Sociale, Collège de France, 52 rue Cardinal Lemoine, 75005 Paris, France |
| |
Abstract: | Aim of the studyIn Uganda, malaria is the most common disease and Ugandan people largely rely on traditional medicine. In this context, we carried out an ethnobotanical study on the Kiohima village, located close to the Kibale National Park in South-Western Uganda and investigated in vitro the antiplasmodial and cytotoxic activities of selected medicinal plants.Materials and methodsSeventy-five plants-using adults (men and women) were interviewed to find out their plant use. From these information, 48 plants used in traditional medicine were identified and according to their reported uses and to bibliographic data, several parts of 28 plants (leaves, barks, roots), were selected and collected for biological evaluations. These samples were dried, extracted with ethyl acetate and the crude extracts were assayed for in vitro antiplasmodial and cytotoxic activities at 10 μg/mL.ResultsOne third of the screened plants showed a significant antiplasmodial activity with inhibition greater than 50% at 10 μg/mL.ConclusionThese results may indicate a possible explanation of the use of some medicinal plant against malaria in the village of Kiohima and have also allowed to highlight a plant with potent antimalarial activity: Citropsis articulata root barks. |
| |
Keywords: | Traditional medicine Uganda Malaria Plasmodium falciparum |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|