| 脓毒症免疫功能紊乱及免疫调节治疗 |
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| 引用本文： | 李成荣.脓毒症免疫功能紊乱及免疫调节治疗[J].临床儿科杂志,2010,28(1). |
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| 作者姓名： | 李成荣 |
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| 作者单位： | 深圳市儿童医院,广东深圳,518026 |
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| 摘 要： | 文章扼述脓毒症免疫功能紊乱机制。病原微生物(配体)通过Toll样受体(TLR)等模式识别受体(PRR)启动固有免疫反应,所产生的炎症细胞因子导致促炎反应并触发适应性免疫,诱导初始T细胞分为Th1、Th2细胞、CD4+CD25+Foxp3+调节性细胞(Treg)及Th17细胞,介导免疫抑制和炎症反应。脓毒症促炎/抗炎反应同时异常活化,导致免疫功能紊乱。免疫调节治疗脓毒症的思路是既能清除内、外源性配体抑制PRR持续活化,又不过度抑制抗感染免疫反应。
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| 关 键 词： | 脓毒症 Toll样受体 固有免疫/适应性免疫 调节性T细胞 Th17细胞 免疫调节治疗 |
Pathogenesis of immune dysfunction in septic and immunoregulation therapy |
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| LI Cheng-rong.Pathogenesis of immune dysfunction in septic and immunoregulation therapy[J].The Journal of Clinical Pediatrics,2010,28(1). |
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| Authors: | LI Cheng-rong |
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| Institution: | Shenzhen Children's Hospital/a>;Shenzhen 518026/a>;Guangdong/a>;China |
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| Abstract: | The pathogenesis of immune dysfunction in septic has been summarized in this review. Innate immune response toward pathogens is initiated by pattern recognition receptor ( PRR) such as Toll-like receptor ( TLR) . Inflammatory cytokines derived from innate immune response not only cause inflammatory response,but also trigger adaptive immune responses through inducing the differentiation of naive T cell into Th1,Th2,CD4 +CD25 +Foxp3 + regulatory T cells ( Treg) ,and Th17 cells. Adaptive immune response might ... |
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| Keywords: | sepsis Toll-like receptor innate/ adaptive immune responses Treg Th17 immunoregulation therapy |
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