肺血栓栓塞症患者高敏C反应蛋白水平与肺动脉压相关性的研究

目的探讨急、慢性肺血栓栓塞症患者血清高敏C反应蛋白（high-sensitive C-reactive protein,hs-CRP）的差异及其与肺动脉压之间的相关性。方法选择肺血栓栓塞症患者102例,其中急性44例,慢性58例。所有患者均经多普勒超声心动图检查,将两组患者各自分为肺动脉压正常组与高压组,采用颗粒增强免疫透射比浊法检测hs-CRP水平。结果急性组hs-CRP（24.0±13.4 mg/L）明显高于慢性组（5.2±4.6 mg/L）（P〈0.01）。急性患者中肺动脉压正常组与高压组hs-CRP无明显差异（P=0.338）。慢性患者肺动脉压正常组hs-CRP（3.3±3.0）明显低于高压组（9.5±4.7 mg/L）（P〈0.05）。慢性肺血栓栓塞症肺动脉高压组患者hs-CRP水平和肺动脉压呈正相关（P〈0.05）。结论急性肺血栓栓塞症患者血清hs-CRP水平明显升高,慢性肺血栓栓塞症肺动脉高压组患者血清hs-CRP水平和肺动脉压显著相关。血清hs-CRP水平可用于PTE的危险分层及判断预后。

Study on relationship between high-sensitivity C-reactive protein and pulmonary artery hypertension in patients with pulmonary embolism

Objective To evaluate the difference of serum hs-CRP in patients with a diagnosis of acute pulmonary embolism and patients with chronic pulmonary embolism,and the correlation between the values of hs-CRP and pulmonary artery pressure.Methods 102 patients received the investigation,including 44 acute pulmonary embolism patients and 58 chronic pulmonary embolism patients.According to Doppler echocardiography,they were divided into two groups——normal pulmonary artery pressure group and pulmonary artery hypertension group.Particle-enhanced turbid metric immunoassay（PETIA） was used to detect hs-CPR level in enrolled patients.Results The hs-CRP level was distinctively higher in patients with acute pulmonary embolism than that in patients with chronic pulmonary embolism（24.0±13.4 mg/L to 5.2±4.6 mg/L,P〈0.01）.There was not significantly hs-CRP difference between in acute pulmonary embolism patients with normal pulmonary artery pressure group versus pulmonary artery hypertension group（P=0.338）.The hs-CRP level was evidently lower in patients with chronic pulmonary embolism in normal pulmonary artery pressure group than that in pulmonary artery hypertension group-the values were（3.3±3.0 versus 9.5±4.7,P〈0.05）.It was indicated that hs-CRP level in patients with chronic pulmonary embolism in pulmonary artery hypertension group had positive correlation with pulmonary artery pressure（P〈0.05）.Conclusion The serum hs-CRP level was obviously elevated in patients with acute pulmonary embolism,while that was also proven highly correlated to pulmonary artery pressure in patients belonging to pulmonary artery hypertension group with chronic pulmonary embolism.The serum hs-CRP level can be used in PE risk stratification and clinical diagnosis.