| 血管紧张素转化酶基因的插入/缺失多态性与心肌梗死的关系 |
| |
| 引用本文： | 田丽红,回皓升,刘彩琼. 血管紧张素转化酶基因的插入/缺失多态性与心肌梗死的关系[J]. 中国综合临床, 2000, 16(11): 807-808 |
| |
| 作者姓名： | 田丽红 回皓升 刘彩琼 |
| |
| 作者单位： | 1. 广东医学院附属医院心内科,湛江,524001
2. 广东医学院生化教研室 |
| |
| 摘 要： | 目的 探讨国人血管紧张素转化酶（ＡＣＥ）基因的插入／缺失（Ｉ／Ｄ）多态性与心肌梗死的关系。方法 应用多聚酶链反应方法检测ＡＣＥ基因多态性。结果 心肌梗死患者ＡＣＥ基因ＤＤ型频率（０．３８）及Ｄ等位基因频率（０．５８）均明显高于对照组。结论国人ＡＣＥ基因ＤＤ型与心肌梗死有关，可能是发生心肌梗死的重要因素之一。
|
| 关 键 词： | 血管紧张素转化酶 基因多态性 心肌梗死 |
Association between the insertion/deletion polymorphism of angiotensin converting enzyme gene and the myocardial infarction |
| |
| Tian Lihong,Hui Haosheng,Liu Caiqiong. Association between the insertion/deletion polymorphism of angiotensin converting enzyme gene and the myocardial infarction[J]. Clinical Medicine of China, 2000, 16(11): 807-808 |
| |
| Authors: | Tian Lihong Hui Haosheng Liu Caiqiong |
| |
| Abstract: | Objective To investigate the association between the insertion/deletion(I/D) polymorphism of angiotensin converting enzyme (ACE) gene and the myocardial infarction (MI) among Chinese population. Methods Polymerase chain reaction(PCR) was applied to the examination of ACE gene polymorphism. A comparison was performed between 50 patients with MI and another 50 healthy subjects.Results The frequencies of DD genotype (0.38) and D allele (0.58) were both higher among the MI group than that among the control group (0.16 and 0.41 respectively,P<0.05).Conclusion The ACE/DD genotype is associated with MI morbidity,which might be an important risk factor for MI among the Chinese population. |
| |
| Keywords: | Angiotensin converting enzyme Gene polymorphism Myocardial infarctioL |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
