复方钩藤降压片对自发性高血压大鼠血压及炎症水平的影响

目的:试从干预高血压病炎症的角度,为复方钩藤降压片治疗高血压病及防治靶器官损害提供理论依据。方法:21只7周龄雄性自发性高血压大鼠(SHR)随机分为3组:模型组(SHR-S组)、复方钩藤降压片组(SHR-G组)、缬沙坦组(SHR-D组),另7只WKY大鼠为空白对照组(WKY组)。无创测压仪测量血压,连续干预6周,ELISA法测定血清CRP、TNF-α、IL-6的水平。结果:1对血压的影响:自第1周开始,SHR-G组血压均低于SHR-S组(P<0.01),而均较SHR-D组、WKY组高(P<0.01),一直持续到实验结束;实验前后血压值比较:SHR-S组治疗前较治疗后升高(P<0.01),SHR-G组与SHR-D组治疗前较治疗后减低(P<0.01);2对炎症因子的影响:SHR-G组及SHR-D组血清CRP、TNF-α、IL-6水平低于SHR-S组,与SHR-D组比较,SHR-G组除血清CRP水平高于SHR-D组(P<0.01),血清TNF-α、IL-6水平无明显差异(P>0.05)。结论:1SHR血压及炎症水平明显升高;2复方钩藤降压片具有较好的降压疗效;3复方钩藤降压片能有效降低高血压病炎症水平,可能是其有效降低血压及防治靶器官损害的机制,具体的抗炎机制还有待进一步研究。

Effect of Compound Uncaria Hypotensive Tablet on Blood Pressure and Inflammatory Level in Spontaneously Hypertensive Rats

Objective： From the intervention of inflammation to provide a theoretical basis for the Compound uncaria hypotensive tablet in the treatment and its effect of target organ damage in hypertension. Methods： 21 seven weeks old male SHR were randomly divided into 3 groups： SHR- S group,SHR- G group and SHR- D group and the other 7 WKY rats into normal control group. The blood pressure was determined by using instrument for measuring blood pressure in rats and the serum 1evels of CRP,TNF- αand IL- 6 were measured by ELISA after six weeks. Results： 1The effect on blood pressure： Since the beginning of the first week,SHR- G group＇s was lower than those of SHR- S group（ P〈0. 01）,but significantly higher than those in SHR- D group and WKY group（ P〈0. 01） until the end of the experiment. Experimental blood pressure value comparison： SHR- S group＇s was elevated after treatment（ P〈0. 01）. SHR- G group and SHR- D group＇s were decreased after treatment（ P〈0. 01）. 2Effect on inflammatory factors in serum： SHR- G and SHR- D groups＇ serum levels of CRP,TNF- αand IL- 6 were lower in the SHR- S group and compared with the SHR-D group,SHR- G group＇s serum level of CRP was higher（ P〈0. 01） and serum levels of TNF- αand IL- 6 had no significant difference between the two groups（ P〈0. 05）. Conclusion： 1 SHR blood pressure and inflammation level were significantly elevated. 2Compound uncaria hypotensive tablet has good antihypertensive effect. 3Tablets can effectively reduce the level of inflammatory of hypertension,which may be its mechanism of effectively lowering blood pressure and target organ damage prevention and its anti- inflammation mechanism remains to be further studied.