慢性扁桃体炎早期肾损害的探讨

目的:探讨慢性扁桃体炎患者是否存在早期肾损害。方法:77例慢性扁桃体炎患者按病程分为3组,A组:病程1～3年,B组:病程>3～5年,C组:病程>5年;另选20例健康志愿者为对照组。采用酶联免疫吸附法(ELISA)进行尿微量白蛋白测定并取其均值作比较,并对其中获随访的19例慢性扁桃体炎患者手术治疗前、后的尿微量白蛋白含量进行比较。结果:①A、B、C组尿微量白蛋白值分别为(9.8±1.6)mg/L、(12.3±2.2)mg/L、(17.6±3.2)mg/L,对照组为(9.6±2.0)mg/L,C组明显高于对照组(P<0.05)。②19例获随访的慢性扁桃体炎患者手术治疗前、后的尿微量白蛋白值分别为(26.3±2.2)mg/L和(18.7±1.7)mg/L(P<0.05)。结论:慢性扁桃体炎患者随病程的增长其尿微量白蛋白有排泌增加的趋势;尿微量白蛋白的检测可以列为慢性扁桃体炎早期肾损害的参考诊断指标之一;其检测对慢性扁桃体炎手术疗效评价具有重要意义。

Investigate the early impairment of renal function caused by chronic tonsillitis

OBJECTIVE: To investigate whether the chronic tonsillitis have early impairment of renal function or not. METHOD: Enzyme linked immunosorbent assay (ELISA) was used to detect the urinary microalbumin of 77 samples of chronic tonsillitis (group A: course of diseases is 1 to 3 years; group B: course of diseases is 3 to 5 years; group C: course of diseases is over 5 years) and 20 samples of normal (group D) respectively and the results were compared, including the detection and comparision of the urinary microalbumin of 19 samples of chronic tonsillitis preoperative and postoperative. RESULT: (1) group A: the urinary microalbumin is (9.8 +/- 1.6)mg/L; group B: the urinary microalbumin is (12.3 2.2) mg/L; group C: the urinary microalbumin is (17.6 +/- 3.2)mg/L; group D: the urinary microalbumin is (9.6 +/- 2.0) mg/L. The urinary microalbumin of chronic tonsillitis group C was higher than group D, there was a significant difference between these two groups ( P < 0.05). (2) The urinary microalbumin of chronic tonsillitis was (26.3 +/- 2.2)mg/L preoperatively and was (18.7 +/- 1.7)mg/L postoperatively. The urinary microalbumin of chronic tonsillitis significantly decreased after they had been surgical treated (P < 0.05). CONCLUSION: The urinary microalbumin of chonic tonsillitis was uptrend according to its course of diseases. The detection of the urinary microalbumin could be one of the diagnostic message for the early impairment of renal function which has been caused by chronic tonsillitis. The detection of the urinary microalbumin is important to evaluate the surgical treatment of chronic tonsillitis.