| 党参总碱对东莨菪碱引起小鼠记忆障碍和脑内乙酰胆碱及胆碱乙酰化酶的作用 |
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| 引用本文： | 潘思源,张禹昉,刘源,徐秋萍,姜名瑛,郭亚健.党参总碱对东莨菪碱引起小鼠记忆障碍和脑内乙酰胆碱及胆碱乙酰化酶的作用[J].中药药理与临床,1992(5). |
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| 作者姓名： | 潘思源 张禹昉 刘源 徐秋萍 姜名瑛 郭亚健 |
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| 作者单位： | 北京中医学院药理教研室，北京中医学院药理教研室，北京中医学院药理教研室，北京中医学院药理教研室，北京中医学院药理教研室，北京中医学院药理教研室 北京 100029，北京 100029，北京 100029，北京 100029，北京 100029，北京 100029 |
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| 摘 要： | 用跳台法观察到党参总碱(DSA)能改善东莨菪碱(Scop)引起的记忆障碍,并能对抗Scop所致小鼠脑内乙酰胆碱(ACh)浓度下降及胆碱乙酰化酶(ChAT)活性的降低。体外实验发现当在反应液中加入DSA后,ChAT生成ACh的量增加。
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| 关 键 词： | 党参总碱 束莨菪碱 乙酰胆碱 胆碱乙酰化酶 记忆障碍 |
Effects of alkaloids of Dangshen (Codonopsis pilosula) on amnesia induced by scopolamine and the acetylcholine and choline acetyltransferase of brain in mice |
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| Pan Siyuan et al.Effects of alkaloids of Dangshen (Codonopsis pilosula) on amnesia induced by scopolamine and the acetylcholine and choline acetyltransferase of brain in mice[J].Pharmacology and Clinics of Chinese Materia Medica,1992(5). |
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| Authors: | Pan Siyuan |
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| Abstract: | In step-down test the alkaloids of Codonopsis pilosula (DSA) had protective effect oa scopolamine (Scop)-induced amnesia. However, DSA did not show antagonistic action on pentobarbital, cycloheximide and ethanol-caused amnesia. DSA did not influence the acetylcholine (ACh) content and choline acetyltransf erase (ChAT) activity of brain in normal mice but prevented the effects of Scop-produced ChAT inhibition and decraese in concentration of ACh in vivo. DSA increased the synthesis of ACh in vitro. |
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| Keywords: | alkaloids of Dangshen scopolamine acetylcholine choline acetyltransf- erase amnesia |
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