| 神经节苷酯对大鼠颅脑损伤后血清神经元特异性烯醇化酶和学习记忆的影响 |
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| 引用本文： | 杨涛,刘清军,朱军,李建民.神经节苷酯对大鼠颅脑损伤后血清神经元特异性烯醇化酶和学习记忆的影响[J].华北煤炭医学院学报,2010,12(1):3-4. |
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| 作者姓名： | 杨涛 刘清军 朱军 李建民 |
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| 作者单位： | 华北煤炭医学院附属医院神经外科,河北唐山,063000 |
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| 摘 要： | ①目的探讨神经节苷酯（GM-1）对大鼠颅脑损伤后血清神经元特异性烯醇化酶和学习记忆的影响。②方法采用Marmarou的方法建立大鼠重型闭合性颅脑创伤模型,将120只SD大鼠随机分为创伤组、治疗组、假手术组及对照组,前3组各36只分为伤后6、12、24、48、72 h5个时相组,每亚组6只,进行血清神经元特异性烯醇化酶检测,余6只进行Morris水迷宫测试;对照组12只,其中6只进行血清神经元特异性烯醇化酶检测,另6只进行Morris水迷宫测试。③结果GM-1能够使大鼠颅脑损伤后血清神经元特异性烯醇化酶的高峰明显下调并改善学习记忆功能。④结论GM-1可能是治疗脑损伤的有效药物。
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| 关 键 词： | 脑损伤 神经节苷脂 神经元特异性烯醇化酶 学习记忆 大鼠 |
Effect of ganglioside on neuron specific enolase in serum and cognitive ability following traumatic brain injury in rats |
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| YANG Tao,LIU Qingjun,ZHU Jun,et al.Effect of ganglioside on neuron specific enolase in serum and cognitive ability following traumatic brain injury in rats[J].Journal of North China Coal Medical College,2010,12(1):3-4. |
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| Authors: | YANG Tao LIU Qingjun ZHU Jun |
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| Institution: | Department of Neurosurgery/a>;Affiliated Hospital of North China Coal Medical University/a>;Tangshan 063000/a>;China |
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| Abstract: | Objective To explore the effect of ganglioside on cognitive ability and neuron specific enolase(NES) in serum following traumatic brain injury(TBI) in rats.Methods The model of severe closed TBI was established according to the method created by Marmarou.120 SD rats were divided randomly into TBI group,treated group,sham operation group and control group,the first 3 groups of 36 rats were divided into five-phase groups,such as 6,12,24,48,72h after injury(each subgroup n=6),then NES in serum were detected in... |
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| Keywords: | Brain injury Ganglioside Neuron specific enolase Cognitive ability Rats |
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