血脂中COL/LDL-C的比值与HS-CRP的测定在心血管疾病中的意义

目的超敏C反应蛋白(hs-CRP)与胆固醇比上高密度脂蛋白胆固醇的值(COL/HDL-C)在糖尿病、心血管疾病中的作用。方法超敏C反应蛋白的测定采用胶乳免疫比浊法,总胆固醇、三酰甘油、高密度与低密度脂蛋白胆固醇的测定采用一步法和氧化酶法。结果 COL/HDL-C,hs-CRP在高血压组,急性心肌梗死组(AMI)和冠心病组(CAD)与健康对照组比较,均显著升高(P<0.01)。并且急性梗死组(AMI)显著高于冠心病(CAD)组(P<0.01),冠心病组(CAD)高于高血压组(P<0.05)。结论 hs-CRP浓度和糖尿病、心血管疾病及其病变程度明显相关,同时检测hs-CRP与TC/HDL-C能提高对糖尿病和心血管疾病的预测以及危险程度的评估。

Lipids in COL/LDL-C Ratio and HS-CRP Determination of Significance in Cardiovascular Disease

Objective To investigate the role of high-sensitivity C-reactive protein （hs-CRP） and ratio of total cholesterol to HDL-cholesterol （TC/HDL-C） in cardiovascular disease. Methods hs-CRP was determined by latex -enhanced immunoturbidimetric assay, TG, TC, HDL-C, LDL-C was determined by enzyme methods and homogeneous method. Results The level of hs-CRP and TC/HDL-C in patients were significantly higher than in the controls. The level of hs-CRP and TC/HDL-C in active myocardial infarction （AMI） was significantly higher than in the coronary artery disease （CAD） . The level of hs-CRP and TC/HDL-C in CAD was significantly higher than in hypertension patient. Conclusions Hs-CRP was strongly associated with cardiovascular disease. It is the stronger risk assessment and predictor of diabetes mellitus and cardiovascular using both hs-CRP and TC/HDL-C ratio.